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LEVOS - Levofloxacin and Rifampicin Therapy in the Treatment of OsteoArticular Prothethic Infection

16:09 EDT 24th April 2014 | BioPortfolio


The primary objective is: to assess the microbiological success of the combination of levofloxacin and rifampicin, administered for 32 to 37 days, as oral replacement therapy of an empirical antibiotic therapy of a maximum of 5 to 10 days given intravenously, in the treatment of OsteoArticular Prosthetic Infections (OAPI), with a two-stage revision of the prosthesis.

The secondary endpoints are:

- To assess the rate of clinical failure 12 months after the reimplantation of the prosthesis.

- To assess the joint mobility function score 12 months after the reimplantation of the prosthesis.

- To assess the safety of the combination of levofloxacin and rifampicin.

- To investigate prognostic factors for success after the end of treatment and at 12 months after the reimplantation of the prosthesis.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment




Levofloxacin (HR355) and Rifampicin Therapy


Sanofi-Aventis Administrative Office





Results (where available)

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Medical and Biotech [MESH] Definitions

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Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

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