Immune Responses in Caucasian and Chinese Participants Exposed to the Epstein-Barr Virus
RATIONALE: Studying samples of blood from participants exposed to the Epstein-Barr virus in the laboratory may help doctors learn more about changes that occur in the immune system.
PURPOSE: This laboratory study is looking at immune responses in Caucasian and Chinese participants exposed to the Epstein-Barr virus.
- Compare immune responses to the Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) in Caucasian vs Asian/Chinese participants.
- Determine a comprehensive T-cell epitope mapping of the EBV-encoded LMP-2 in these ethnically diverse populations.
OUTLINE: Participants undergo apheresis for the collection of autologous peripheral blood mononuclear cells (PBMC). PBMC are analyzed for HLA type by sequence-based typing and immune-dominant epitopes of Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) by epitope mapping.
PROJECTED ACCRUAL: A total of 60 participants (30 Caucasian and 30 Asian/Chinese) will be accrued for this study within 2 years.
Health Status Unknown
gene mapping, microarray analysis, polymorphism analysis
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
National Cancer Institute (NCI)
Results (where available)
- Source: http://clinicaltrials.gov/show/NCT00897156
- Information obtained from ClinicalTrials.gov on July 15, 2010
RATIONALE: Studying samples of blood or tumor tissue from patients with cancer in the laboratory may help doctors learn about changes that occur in DNA and identify biomarkers related to c...
RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. ...
RATIONALE: Identifying genes that increase a person's susceptibility or resistance to hepatitis B virus infection may help the study of hepatitis. PURPOSE: This clinical trial is studying...
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Clinical trial to study the cancer-related genes i...
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women ...
Abstract Background: Several studies have reported an association between the UBQ-8i (rs12344615) polymorphism of the UBQLN1 gene and risk of Alzheimer's disease (AD), but these findings remain contro...
To report the full cohort of identifiable anomalies, regardless of known clinical significance, in a large-scale cohort of postmiscarriage products-of-conception samples analyzed using a high-resoluti...
Abstract Association of vitamin D receptor (VDR) BsmI (rs1544410) gene polymorphism with the chronic kidney disease (CKD) susceptibility from the published reports are still conflicting. This meta-ana...
Objective: To assess the association between myeloperoxidase (MPO) gene polymorphism and coronary artery disease (CAD). Methods: Several databases were used to retrieve relevant literature up to March...
To investigate whether gene expression profiles can be used to determine risk genes and predict HBV-related cirrhosis progression to liver carcinoma using Significance Analysis of Microarray (SAM) and...
Medical and Biotech [MESH] Definitions
The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.
A multistage process that includes DNA cloning, physical mapping, subcloning, sequencing, and information analysis.
A multistage process that includes RNA cloning, physical mapping, subcloning, sequencing, and information analysis.
A center in the PUBLIC HEALTH SERVICE which is primarily concerned with the collection, analysis, and dissemination of health statistics on vital events and health activities to reflect the health status of people, health needs, and health resources.
Hybridization of a nucleic acid sample to a very large set of oligonucleotide probes, which are attached to a solid support, to determine sequence or to detect variations in a gene sequence or expression or for gene mapping.