Immune Responses in Caucasian and Chinese Participants Exposed to the Epstein-Barr Virus

18:24 EDT 29th March 2015 | BioPortfolio

Summary

RATIONALE: Studying samples of blood from participants exposed to the Epstein-Barr virus in the laboratory may help doctors learn more about changes that occur in the immune system.

PURPOSE: This laboratory study is looking at immune responses in Caucasian and Chinese participants exposed to the Epstein-Barr virus.

Description

OBJECTIVES:

- Compare immune responses to the Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) in Caucasian vs Asian/Chinese participants.

- Determine a comprehensive T-cell epitope mapping of the EBV-encoded LMP-2 in these ethnically diverse populations.

OUTLINE: Participants undergo apheresis for the collection of autologous peripheral blood mononuclear cells (PBMC). PBMC are analyzed for HLA type by sequence-based typing and immune-dominant epitopes of Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) by epitope mapping.

PROJECTED ACCRUAL: A total of 60 participants (30 Caucasian and 30 Asian/Chinese) will be accrued for this study within 2 years.

Study Design

N/A

Conditions

Health Status Unknown

Intervention

gene mapping, microarray analysis, polymorphism analysis

Location

Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
Bethesda
Maryland
United States
20892-1182

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

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