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RATIONALE: Studying samples of blood from participants exposed to the Epstein-Barr virus in the laboratory may help doctors learn more about changes that occur in the immune system.
PURPOSE: This laboratory study is looking at immune responses in Caucasian and Chinese participants exposed to the Epstein-Barr virus.
- Compare immune responses to the Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) in Caucasian vs Asian/Chinese participants.
- Determine a comprehensive T-cell epitope mapping of the EBV-encoded LMP-2 in these ethnically diverse populations.
OUTLINE: Participants undergo apheresis for the collection of autologous peripheral blood mononuclear cells (PBMC). PBMC are analyzed for HLA type by sequence-based typing and immune-dominant epitopes of Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) by epitope mapping.
PROJECTED ACCRUAL: A total of 60 participants (30 Caucasian and 30 Asian/Chinese) will be accrued for this study within 2 years.
Health Status Unknown
gene mapping, microarray analysis, polymorphism analysis
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-26T22:22:20-0400
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