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Immune Responses in Caucasian and Chinese Participants Exposed to the Epstein-Barr Virus

17:38 EDT 17th April 2014 | BioPortfolio

Summary

RATIONALE: Studying samples of blood from participants exposed to the Epstein-Barr virus in the laboratory may help doctors learn more about changes that occur in the immune system.

PURPOSE: This laboratory study is looking at immune responses in Caucasian and Chinese participants exposed to the Epstein-Barr virus.

Description

OBJECTIVES:

- Compare immune responses to the Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) in Caucasian vs Asian/Chinese participants.

- Determine a comprehensive T-cell epitope mapping of the EBV-encoded LMP-2 in these ethnically diverse populations.

OUTLINE: Participants undergo apheresis for the collection of autologous peripheral blood mononuclear cells (PBMC). PBMC are analyzed for HLA type by sequence-based typing and immune-dominant epitopes of Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) by epitope mapping.

PROJECTED ACCRUAL: A total of 60 participants (30 Caucasian and 30 Asian/Chinese) will be accrued for this study within 2 years.

Study Design

N/A

Conditions

Health Status Unknown

Intervention

gene mapping, microarray analysis, polymorphism analysis

Location

Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
Bethesda
Maryland
United States
20892-1182

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.

A multistage process that includes DNA cloning, physical mapping, subcloning, sequencing, and information analysis.

A multistage process that includes RNA cloning, physical mapping, subcloning, sequencing, and information analysis.

A center in the PUBLIC HEALTH SERVICE which is primarily concerned with the collection, analysis, and dissemination of health statistics on vital events and health activities to reflect the health status of people, health needs, and health resources.

Hybridization of a nucleic acid sample to a very large set of oligonucleotide probes, which are attached to a solid support, to determine sequence or to detect variations in a gene sequence or expression or for gene mapping.

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