Role of Laparoscopy in Unexplained Infertility
Summary
In this randomized controlled trial the investigators were looking for the best policy for management of women with unexplained infertility after normal hysterosalpingogram (HSG). The investigators test the hypothesis that postponing or even bypassing laparoscopy does not affect the outcome of management of women with apparently unexplained infertility.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Infertility
Intervention
laparoscopy, ovarian stimulation
Location
Mansoura University Hospitals
Mansoura
Dakahalia
Egypt
35000
Status
Completed
Source
Mansoura University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00886041
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Ovarian Hyperstimulation Syndrome
A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.
Laparoscopy
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Infertility
Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.
Ovarian Failure, Premature
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.
Primary Ovarian Insufficiency
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.
Clinical Trials
Gonadotropin-releasing Hormone (GnRH) Antagonist During 3 Days
In this prospective study, the investigators would like to show whether ovarian stimulation with pretreatment of a GnRH antagonist during 3 consecutive days at initiation of the cycle, is...
The etiology of infertility in the majority of patients with poor response to ovarian stimulation remains unknown. This study will investigate the role of immune cells (T cells, B cells,...
Synchronization of Follicle Wave Emergence and Ovarian Stimulation
The objective of the study is to elucidate the effect of synchronizing initiation of ovarian stimulation treatment with follicular wave emergence in poor responder patients undergoing IVF/...
The primary objective of this study is to determine whether the addition of Luveris® to follicle stimulating hormone (FSH) at day 8 of ovarian stimulation can reduce the dose and/or durat...
The purpose of this study is to show that a single injection of SCH 900962 is non-inferior to daily injections of recFSH during the first week of ovarian stimulation in terms of the number...
PubMed Articles
Ovarian stimulation and the risk of aneuploid conceptions.
OBJECTIVE: To examine the rate of aneuploidy in missed abortions in patients who conceived after FSH ovarian stimulation compared with women who conceived in a natural cycle. DESIGN: Retrospective coh...
Aim: Laparoscopy is the gold standard for treatment of benign ovarian cysts, although there is a risk of intraoperative cyst rupture if the lesion is cancerous. This study is aimed at comparing the...
Mild ovarian stimulation for in vitro fertilization: one perspective from the USA.
PURPOSE: To provide a perspective regarding mild ovarian stimulation, taking into account particular issues relevant in the United States METHODS: Literature review and editorial commentary RESULTS: M...
Hormonal and ultrasound markers of ovarian function in a woman with a balanced 1;11 translocation.
OBJECTIVE: To present a case of a poor responder woman with a rare balanced autosomal translocation. DESIGN: Case report. SETTING: Infertility center in a university teaching hospital. PATIENT(S): A 3...
INTRODUCTION: Mild ovarian stimulation has been conceived, proposed and implemented in clinical practice as a safer and cheaper alternative to conventional strategies of controlled ovarian hyperstimul...
