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Candesartan Versus Propranolol for Migraine Prevention

2014-07-23 21:14:43 | BioPortfolio

Summary

The main aim of the present study is to compare candesartan with propranolol for migraine prophylaxis.

Description

Candesartan was shown to be effective for migraine prophylaxis in a randomized double blind cross-over study published in 2003. The drug is now widely used for this purpose in many countries, although no confirmatory study has been published. The aims of the present study are: 1) to see if the results in the first candesartan study can be replicated in a new patient population, including patients with chronic migraine, and, 2) to perform a head-to-head comparison of candesartan 16 mg/day with standard treatment with propranolol 160 mg slow release. We also intend to study whether responsiveness to these drugs may be related to heart rate variability and baroreceptor sensitivity.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Migraine Without Aura

Intervention

candesartan cilexitil, propranolol hydrochloride, placebo tablets and capsules

Location

Norwegian National headache Centre, St. Olavs Hospital
Trondheim
Norway
7006

Status

Not yet recruiting

Source

Norwegian University of Science and Technology

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:14:43-0400

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Medical and Biotech [MESH] Definitions

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