Safety, Tolerability, and Efficacy of 21 Days Dermal Application of MRX-6 on Mild to Moderate Contact Dermatitis
Summary
A Double-blind, Vehicle-controlled Study to Assess the Safety, Tolerability, and Efficacy of Three Weeks of Daily Dermal Application of MRX-6 or steroid on the Treatment of Mild to Moderate Allergic Contact Dermatitis of the Hand and Forearm.
Total number of patients: up to 80.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Allergic Contact Dermatitis
Intervention
MRX-6, Steroid
Location
Department of Dermatology, Hadassah Hospital
Ein Karem, Jerusalem
Israel
Status
Recruiting
Source
Hadassah Medical Organization
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00867607
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
Dermatitis, Irritant
A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.
Dermatitis, Toxicodendron
An allergic contact dermatitis caused by exposure to plants of the genus Toxicodendron (formerly Rhus). These include poison ivy, poison oak, and poison sumac, all plants that contain the substance urushiol, a potent skin sensitizing agent. (From Dorland, 27th ed)
Tulipa
A plant genus of the family LILIACEAE. Members contain tuliposides and tulipalins and have been associated with allergic contact dermatitis in florists.
Clinical Trials
The current knowledge of the pathophysiology of allergic contact dermatitis is based on the murine model. In this model, CD8+ T cells are effector cells, and CD4+ T cells regulate the re...
Clinical Evaluation of Bacitracin
The purpose of this study is to establish a concentration of a bacitracin-patch for diagnosing allergic contact dermatitis.
The purpose of this study is to compare the effect and safety of rHuPH20 or placebo for the treatment of skin allergic reaction to nickel. The study drug and placebo will be administered...
It is the purpose of this study to determine the concentration of 3 allergens (goldnatriumthiosulphate, methyldibromoglutharonitrile [MDBGN], parthenolide) for diagnosing allergic contact...
A study of subjects with a known nickel allergy comparing Tacrolimus to placebo, both associated with nickel patches to determine the safety and efficacy of treating Chronic Allergic Conta...
PubMed Articles
Diagnosis and management of contact dermatitis.
Contact dermatitis is a common inflammatory skin condition characterized by erythematous and pruritic skin lesions that occur after contact with a foreign substance. There are two forms of contact der...
Pin site allergic contact dermatitis: an unusual complication of halo fixation.
We report a case of halo pin site allergic contact dermatitis, a rare complication of halo vest immobilisation (HVI), necessitating device removal. Although uncommon, pin site allergic contact dermati...
Current Strategies in Treating Severe Contact Dermatitis in Pediatric Patients.
Allergic contact dermatitis in children is underdiagnosed and undertreated, and its incidence is increasing. Appropriate history taking and the suspicion for allergic contact dermatitis is essential,...
Bra-Associated Allergic Contact Dermatitis: P-Tert-Butylphenol Formaldehyde Resin as the Culprit.
P-tert-butylphenol formaldehyde resin (PTBPFR) is recognized as a significant source of allergic contact dermatitis in adults and children in association with athletic gear, shoes, and neoprene. T...
Background: Patch tests are an efficient method to confirm the etiological diagnosis of allergic contact dermatitis.
