Bad Breath Response to Tongue Scraper and Rinses

2014-07-24 09:13:56 | BioPortfolio


Medical center personnel are screened organoleptically for bad breath by 2 investigators using Rosenberg scale 0-5, and measurement of breath sample in gas chromatograph. With a threshold score of 2 or more, or 75ppb H2S, subjects invited to enter clinical trial of the mechanical effect of daily tongue scraping with the adjunctive use of 0.12% chlorhexidine gluconate mouthwash or 0.1% stabilized chlorine dioxide. Subjects randomly assigned in double-blind trial for one week. The null hypothesis is there will be no difference between the two rinses as adjuncts to tongue scraping.


Subjects in trial will have oral and periodontal exam and score the Ramfjord teeth for PlI, GI, PD, recession. A tongue index is scored and sample of coating on dorsum taken for culture of total viable count and % black colonies on anaerobe agar with sulfur added. Subjects given hygiene instruction and instruction on use of scraper, then rinse with 20ml assigned mouthwash 30sec. Breath assessed by organoleptic means and mouth air sample in chromatograph at 0, 1, 2, and 4 hours. Subjects use scraper and mouthwash twice daily for one week and return for final exam.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Bio-equivalence Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment




stabilized chlorine dioxide mouthwash, chlorhexidine gluconate


San Francisco
United States


Enrolling by invitation


University of California, San Francisco

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T09:13:56-0400

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