The Prevalence of HIV Drug Resistance and Transmission Risk in Opioid Agonist Treatment
Summary
HIV drug resistance presents a significant public heath problem. This proposal is designed to explore the association between ongoing illicit drug use and the prevalence of HIV drug resistance among HIV+ opioid dependent patients receiving opioid agonist treatment with the following hypotheses:
1. Hypothesis 1: The prevalence of HIV drug resistance will range between 10% and 30%.
2. Hypothesis 2: Patients with evidence of ongoing illicit drug use will be more likely to have HIV drug resistance.
Study Design
Observational Model: Ecologic or Community, Time Perspective: Cross-Sectional
Conditions
HIV Positive
Location
Yale University Hospital
New Haven
Connecticut
United States
06511
Status
Recruiting
Source
Yale University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00857350
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Positive-pressure Respiration, Intrinsic
Non-therapeutic positive end-expiratory pressure occurring frequently in patients with severe airway obstruction. It can appear with or without the administration of external positive end-expiratory pressure (POSITIVE-PRESSURE RESPIRATION). It presents an important load on the inspiratory muscles which are operating at a mechanical disadvantage due to hyperinflation. Auto-PEEP may cause profound hypotension that should be treated by intravascular volume expansion, increasing the time for expiration, and/or changing from assist mode to intermittent mandatory ventilation mode. (From Harrison's Principles of Internal Medicine, 12th ed, p1127)
Ions
An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
Intermittent Positive-pressure Breathing
Application of positive pressure to the inspiratory phase of spontaneous respiration.
Intermittent Positive-pressure Ventilation
Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.
Gram-positive Asporogenous Rods
A gram-positive, non-spore-forming group of bacteria comprising organisms that have morphological and physiological characteristics in common.
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