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Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder

15:41 EDT 23rd April 2014 | BioPortfolio

Summary

This is an outpatient study to evaluate the safety, and efficacy of RGH-188 as an add-on therapy to standard antidepressants in patients who did not respond to previous antidepressant therapy.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Major Depressive Disorder

Intervention

Antidepressant + placebo, Antidepressant + cariprazine (0.1-0.3 mg/day), Antidepressant + cariprazine (1-2 mg/d)

Location

Forest Investigative Site 040
Phoenix
Arizona
United States
85050

Status

Completed

Source

Forest Laboratories

Results (where available)

View Results

Links

Medical and Biotech [MESH] Definitions

A phosphodiesterase inhibitor with antidepressant properties.

A tricyclic antidepressant with some tranquilizing action.

A tricyclic antidepressant with actions similar to AMITRIPTYLINE.

The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.

A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.

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