Safety and Efficacy of Cariprazine As Adjunctive Therapy In Major Depressive Disorder
Summary
This is an outpatient study to evaluate the safety, and efficacy of RGH-188 as an add-on therapy to standard antidepressants in patients who did not respond to previous antidepressant therapy.
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Conditions
Major Depressive Disorder
Intervention
Antidepressant + placebo, Antidepressant + cariprazine (0.1-0.3 mg/day), Antidepressant + cariprazine (1-2 mg/d)
Location
Forest Investigative Site 040
Phoenix
Arizona
United States
85050
Status
Completed
Source
Forest Laboratories
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00854100
- Information obtained from ClinicalTrials.gov on March 05, 2012
Medical and Biotech [MESH] Definitions
Rolipram
A phosphodiesterase inhibitor with antidepressant properties.
Dothiepin
A tricyclic antidepressant with some tranquilizing action.
Opipramol
A tricyclic antidepressant with actions similar to AMITRIPTYLINE.
Imipramine
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
Viloxazine
A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.
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