A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal

14:56 EDT 2nd September 2014 | BioPortfolio

Summary

The primary objective of this study is to determine the efficacy of phosphatidylcholine and deoxycholate subcutaneous injections for localized fat removal.

Subcutaneous injections of the study drug will be efficacious in decreasing localized fat deposits due to the known fat necrosis effects on fat tissue after study drug tissue incubation.

Study Design

Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Obesity

Intervention

Subcutaneous Phosphatidylcholine and Deoxycholate Injections, Saline

Location

Cleveland Clinic Foundation
Cleveland
Ohio
United States
44195

Status

Terminated

Source

The Cleveland Clinic

Results (where available)

View Results

Links

Clinical Trials [752 Associated Clinical Trials listed on BioPortfolio]

Follow-up Study With Retarded Release Phosphatidylcholine in Ulcerative Colitis

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Effect of Phosphatidylcholine on Plasma Homocysteine in Healthy Volunteers

The purpose of this study is to determine whether supplementation with phosphatidylcholine lowers plasma homocysteine concentrations in healthy men.

Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism

We will be testing a specific dietary supplement, methylcobalamin (vitamin B12). Follow-up assessments with our clinical team will take place over the 12-week study period so that we can ...

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PubMed Articles [4678 Associated PubMed Articles listed on BioPortfolio]

A Histopathologic and Immunohistochemical Study on Liquification of Human Adipose Tissue Ex Vivo.

This preliminary ex vivo study aimed to clarify the pathophysiologic mechanisms of fat tissue depletion by subcutaneous drug application. Therefore, the lipolytic effects of phosphatidylcholine plus d...

Patients on subcutaneous allergen immunotherapy are at risk of intramuscular injections.

Allergen-specific subcutaneous immunotherapy is an effective treatment for certain allergic disorders. Ideally, it should be administered into the subcutaneous space in the mid-posterolateral upper ar...

A65: procedural pain with weekly injections of subcutaneous methotrexate in children with rheumatic disorders.

Procedural pain may have long-term negative effects on children. The aim of this study was to evaluate the amount of pain associated with weekly subcutaneous injections of methotrexate.

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch.

A clear relationship exists between visceral obesity and type 2 diabetes, whereas subcutaneous obesity is comparatively benign. Here, we show that adipocyte-specific deletion of the coregulatory prote...

Electroacupuncture reduces hyperalgesia after injections of acidic saline in rats.

Background. Injections of acidic saline into the gastrocnemius muscle in rats produce a bilateral long-lasting hyperalgesia similar to fibromyalgia in humans. No previous study investigated the effect...

Medical and Biotech [MESH] Definitions

Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.

Removal of localized SUBCUTANEOUS FAT deposits by SUCTION CURETTAGE or blunt CANNULATION in the cosmetic correction of OBESITY and other esthetic contour defects.

The application of medicine, vitamins, extracts, or other bioactive substances for a localized effect via multiple subcutaneous injections or perfusion of substances into the various layers of the skin below the EPIDERMIS.

Injections introduced directly into localized lesions.

Injections into the lymph nodes or the lymphatic system.

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