Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study
Summary
Previously the investigators have found that adolescent elite swimmers, who have been involved in competitive swimming for only a few years, have not developed respiratory symptoms, signs of airway inflammation or airway hyperresponsiveness exept for a slight increase in airway responsiveness to eucapnic voluntary hyperpnea. In the current study, the investigators will be doing a 3-year follow-up study on the swimmers studied previously.
Description
Even though studies suggest that elite sport can cause AHR and airway inflammation, more studies are needed to elucidate how and when AHR and airway inflammation develop; and there is a lack of follow-up studies. The present study will give us a chance to do a follow-up study to register changes in AHR and airway inflammation in athletes without any significant airway changes at baseline.
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Conditions
Asthma
Location
Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Bispebjerg Hospital
Copenhagen
Denmark
2400
Status
Recruiting
Source
Bispebjerg Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00841425
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Asthma, Exercise-induced
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Anti-asthmatic Agents
Drugs that are used to treat asthma.
Orciprenaline
A beta-adrenergic agonist used in the treatment of asthma and bronchospasms.
Tretoquinol
An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.
Isoetharine
Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.
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