An Alternative Dosing Schedule of Varenicline for Smoking Cessation
Summary
The purpose of this study is to explore the use of an prolonged alternative dosing schedule using varenicline for smoking cessation leading to greater quit rates and higher rates of continuous abstinence.
Description
This pilot study will utilize a two group randomized design. Adult smokers who are motivated to quit smoking will be randomized to one of two treatment groups. Both groups will receive brief support counseling. During a one-week baseline and the 4-week pre-quit period smoking rate, smoking satisfaction, withdrawal, and craving will be assessed on a daily basis.
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Smoking Cessation
Intervention
varenicline, placebo
Location
Roswell Park Cancer Institute
Buffalo
New York
United States
14263
Status
Active, not recruiting
Source
Roswell Park Cancer Institute
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00835900
- Information obtained from ClinicalTrials.gov on April 04, 2013
Medical and Biotech [MESH] Definitions
Smoking Cessation
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
Tobacco Use Cessation
Cessation of the habit of using tobacco products for smoking or chewing, including the use of snuff.
Bupropion
A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
Lobeline
An alkaloid that has actions similar to NICOTINE on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.
Cognitive Dissonance
Motivational state produced by inconsistencies between simultaneously held cognitions or between a cognition and behavior; e.g., smoking enjoyment and believing smoking is harmful are dissonant.
Clinical Trials
Comparison of Varenicline and Placebo for Smoking Cessation in Schizophrenia
The purpose of this proposed pilot study is to examine the use of varenicline in people with schizophrenia to specifically assess tolerability and efficacy for smoking cessation. Specifica...
Long-term Varenicline Treatment for Smoking Cessation
This is a clinical study of the efficacy and safety of up to 52 weeks of varenicline therapy in conjunction with individual counseling for smoking cessation. Adult volunteers in generally...
Assessment of Safety and Efficacy of Varenicline in Patients That Wish to Stop Smoking
The primary objective of this protocol is to evaluate 12 weeks of treatment of varenicline compared to placebo for smoking cessation. Abstinence from cigarette smoking and other tobacco p...
A Seven-Week Dose-Ranging Study of CP-526,555 Compared With Placebo and Zyban for Smoking Cessation
The purpose of the study is to measure the safety and efficacy of three doses of varenicline for smoking cessation.
Combining Varenicline and Bupropion for Smoking Cessation
Objectives: 1. To evaluate the efficacy of varenicline plus bupropion (VB) vs. varenicline (V) or Placebo (P) alone for smoking cessation, 2. To evaluate the effects of VB...
PubMed Articles
Pharmacoeconomic spotlight on varenicline as an aid to smoking cessationdagger.
Varenicline (Chantix(R), Champix(R)) is an orally administered alpha4beta2 nicotinic acetylcholine receptor partial agonist that is indicated as an aid to smoking cessation. Varenicline was an effecti...
Adynamic Ileus Induced by Varenicline.
Varenicline is a drug specifically developed for smoking cessation. Gastrointestinal symptoms are among the most common side effects (nausea, vomiting, and constipation). Here, we described the case o...
Varenicline is an effective and increasingly prescribed drug for smoking cessation, but has been associated with depressive symptoms and suicidal behavior. However, it remains unclear whether those ch...
A preliminary investigation of varenicline for heavy drinking smokers.
RATIONALE: Varenicline, an approved smoking cessation pharmacotherapy, also shows promise as a potential treatment for alcohol dependence. However, varenicline has not been tested in heavy drinkers, a...
Abstract Objective: A pooled analysis to evaluate the efficacy and safety of varenicline versus placebo for smoking cessation in Asian populations. A secondary objective was to compare the data to poo...
