Comparing Therapeutic Hypothermia Using External and Internal Cooling for Post-Cardiac Arrest Patients
Summary
Controlled therapeutic hypothermia is a method of preserving neurological function post-resuscitation.It has been associated with improved functional recovery and reduced histological deficits in animal models of cardiac arrest.
Description
Three randomized clinical studies have been reported showing improved neurological outcome and reduced mortality in post-resuscitation patients treated with hypothermia compared to controls. Of the various methods of inducing hypothermia, internal cooling using an endovascular catheter and external cooling using gel pads with a water based circulating system have shown the most promise. There have not been any studies looking at outcomes between the two methods of cooling.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Conditions
Cardiac Arrest With ROSC for 30 Minutes
Intervention
Internal Device (Alsius Thermogard), External Device (Arctic Sun)
Location
Singapore General Hospital
Singapore
Singapore
169608
Status
Recruiting
Source
Singapore General Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00827957
- Information obtained from ClinicalTrials.gov on July 15, 2010
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