Alveolar Macrophage Proteomics in HIV-Associated Emphysema
Summary
This study is being done to examine lung function changes in individuals with HIV infection and to understand why individuals with HIV have increased risk of lung damage from cigarette smoking.
Description
To delineate the natural history of HIV associated emphysema in the HAART era. To compare the alveolar macrophage proteomes from HIV-seropositive smokers with emphysema to the alveolar macrophages proteomes of both HIV+ smokers without emphysema and HIV- smokers.
To establish whether coinfection with HIV and Hepatitis C results in accelerated lung disease manifested by decrements in forced expiratory volume and carbon monoxide diffusing capacity.
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Conditions
HIV
Location
The Ohio State University
Columbus
Ohio
United States
43026
Status
Active, not recruiting
Source
Ohio State University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00823927
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Calcimycin
An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
Temefos
An organothiophosphate insecticide.
Abattoirs
Places where animals are slaughtered and dressed for market.
Abbreviations As Topic
Shortened forms of written words or phrases used for brevity.
Abdomen
That portion of the body that lies between the THORAX and the PELVIS.
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