Glycosaminoglycans During Septic Shock - a Temporal Study
Summary
We have previously shown that the plasma level of glycosaminoglycans (GAG) in septic shock patients are elevated compared to controls. The purpose of this study is to investigate the temporal dynamic of the blood level of GAG in ten septic shock patients. In addition, to assess the kinetics of GAG during septic shock we examine the liver function by galactose elimination capacity as well as excreted urinary GAG.
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Conditions
Septic Shock
Location
Intensive Care Unit, Lund University Hospital
Lund
Sweden
22185
Status
Recruiting
Source
Region Skane
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00814112
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Vasoplegia
Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.
Shock, Septic
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Hsp40 Heat-shock Proteins
A family of heat-shock proteins that contain a 70 amino-acid consensus sequence known as the J domain. The J domain of HSP40 heat shock proteins interacts with HSP70 HEAT-SHOCK PROTEINS. HSP40 heat-shock proteins play a role in regulating the ADENOSINE TRIPHOSPHATASES activity of HSP70 heat-shock proteins.
Shock, Traumatic
Shock produced as a result of trauma.
Clinical Trials
Corticosteroid Therapy of Septic Shock - Corticus
The purpose of the study is to determine whether steroids decrease 28-day mortality in patients with septic shock.
Phenylephrine Versus Norepinephrine in Septic Shock
Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on syst...
Thiamine as a Metabolic Resuscitator in Septic Shock
The major goal of this project is to determine whether the use of thiamine in patients with septic shock will result in attenuation of lactic acidosis and a more rapid reversal of shock.
The present study was conducted as a prospective, randomized, controlled study to compare: - the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics...
Tryptophan, Serotonin and Kynurenine in Septic Shock
Septic shock is a major cause of mortality and morbidity worldwide. Serotonin (5-HT) is released by activated platelets into the circulation, and is mediator of endothelial dysfunction. 5-...
PubMed Articles
OBJECTIVE: Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with sh...
Drotrecogin alfa (activated) in septic shock.
To the Editor: Ranieri et al. (May 31 issue)(1) report the results of yet another negative trial involving patients with septic shock. I cannot help but wonder whether these negative trials reflect a...
Drotrecogin alfa (activated) in septic shock.
To the Editor: Ranieri et al. (May 31 issue)(1) report the results of yet another negative trial involving patients with septic shock. I cannot help but wonder whether these negative trials reflect a...
Drotrecogin alfa (activated) in septic shock.
To the Editor: Ranieri et al. (May 31 issue)(1) report the results of yet another negative trial involving patients with septic shock. I cannot help but wonder whether these negative trials reflect a...
Vasopressin and copeptin levels in children with sepsis and septic shock.
PURPOSE: Levels of vasopressin and its precursor copeptin in pediatric sepsis and septic shock are not well defined. The main aim of this study is to compare the serum levels of vasopressin and copept...
