The Effects of Potassium on Physiological and Cardiovascular Variables in Healthy Persons
Summary
In humans living of fruit and vegetables, hypertension is rarely seen. We wish to study if the development of hypertension has a connection to our intake of potassium. We know that fruit and vegetables contain a lot of potassium and we will simulate this intake by giving healthy subjects potassium as tablets.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Hypertension
Intervention
Calcium, Potassium
Location
Department of medical research
Holstebro
Denmark
7500
Status
Active, not recruiting
Source
Holstebro Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00801034
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Large-conductance Calcium-activated Potassium Channels
A major class of calcium activated potassium channels whose members are voltage-dependent. MaxiK channels are activated by either membrane depolarization or an increase in intracellular Ca(2+). They are key regulators of calcium and electrical signaling in a variety of tissues.
Potassium Channels, Calcium-activated
Potassium channels whose activation is dependent on intracellular calcium concentrations.
Intermediate-conductance Calcium-activated Potassium Channels
A major class of calcium-activated potassium channels that were originally discovered in ERYTHROCYTES. They are found primarily in non-excitable CELLS and set up electrical gradients for PASSIVE ION TRANSPORT.
Small-conductance Calcium-activated Potassium Channels
A major class of calcium-activated potassium channels that are found primarily in excitable CELLS. They play important roles in the transmission of ACTION POTENTIALS and generate a long-lasting hyperpolarization known as the slow afterhyperpolarization.
Large-conductance Calcium-activated Potassium Channel Alpha Subu...
The pore-forming subunits of large-conductance calcium-activated potassium channels. They form tetramers in CELL MEMBRANES.
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