Eyelash Growth From Application of Bimatoprost in Gel Suspension to the Base of the Eyelashes
Summary
Objective: To determine if Lumigan (bimatoprost) causes increased lash length when used in gel suspension applied to the base of the eyelashes. Methods: Subjects recruited from the Bascom Palmer Eye Institute were screened and those who met inclusion criteria were enrolled. Each participant received two vials of gel suspension, which contained bimatoprost and normal saline, respectively, each mixed 1:1 with GonakTM gel and labeled "right eye" and "left eye" according to randomization. The suspension was applied to the eyelashes every evening on the designated eye for 6 weeks. Lash length was measured with a caliper at enrollment, at weekly intervals during the study and at 1 and 3 months after study completion. Visual acuity, ocular symptoms, intraocular pressure and photographs were documented at these same intervals. Results: The average eyelash growth in the Lumigan group was 2.01mm (vs. control average of 1.13mm) which was a statistically significant difference (p=0.009). The average intraocular pressure decreased equally in both groups (2.14 mmHg). No change in visual acuity or iris discoloration was noted in any of the subjects. Discussion: Our data showed an increase in eyelash length with use of Lumigan in gel suspension, suggesting that it may have eyelash lengthening properties.
Study Design
Intervention Model: Parallel Assignment
Conditions
Eyelash Lengthening
Intervention
Bimatoprost mixed with Gonak into a gel suspension
Location
University of Miami, Bascom Palmer Eye Institute
Miami
Florida
United States
33136
Status
Completed
Source
University of Miami
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00773136
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Bone Lengthening
Increase in the longest dimension of a bone to correct anatomical deficiencies, congenital, traumatic, or as a result of disease. The lengthening is not restricted to long bones. The usual surgical methods are internal fixation and distraction.
Minor Lymphocyte Stimulatory Antigens
Endogenous superantigens responsible for inducing strong proliferative responses in T-cells in mixed lymphocyte reactions (see LYMPHOCYTE CULTURE TEST, MIXED). They are encoded by mouse mammary tumor viruses that have integrated into the germ line as DNA proviruses (MINOR LYMPHOCYTE STIMULATORY LOCI).
Sleep
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
Peptide Chain Elongation, Translational
A process of GENETIC TRANSLATION, when an amino acid is transferred from its cognate TRANSFER RNA to the lengthening chain of PEPTIDES.
Orthodontic Extrusion
Orthodontic movement in the coronal direction achieved by outward tension on the PERIODONTAL LIGAMENT. It does not include the operative procedure that CROWN LENGTHENING involves.
Clinical Trials
This study will evaluate the safety and efficacy of bimatoprost solution 0.03% once daily to the upper eyelid margins (where the eyelashes meet the skin) compared with vehicle in increasin...
This study will evaluate the safety and efficacy of bimatoprost solution 0.03% once daily application to the upper eyelid margins compared with vehicle in treating eyelash loss or hypotric...
Safety and Efficacy of Bimatoprost Solution in Increasing Overall Eyelash Prominence
This study evaluates the safety and effectiveness of topical bimatoprost solution for enhancing eyelash prominence.
RATIONALE: Bimatoprost ophthalmic solution may help increase eyebrow and eyelash growth in patients who have undergone chemotherapy. PURPOSE: This randomized clinical trial is studying ho...
Bioavailability of Bimatoprost Ophthalmic Solution in Human Aqueous.
The purpose of this study is to assay human aqueous for bimatoprost and the presence of any metabolites, especially prostaglandin analogs. Hypothesis:Bimatoprost is not metabolized to a pr...
PubMed Articles
Topical bimatoprost for the treatment of eyebrow hypotrichosis.
Topical bimatoprost was FDA approved in December of 2008 for the treatment of eyelash hypotrichosis. Since its approval, some physicians have advocated the use of bimatoprost "off label" for hair grow...
Adverse periocular reactions to five types of prostaglandin analogs.
PurposeWe investigated the appearance frequency of eyelid pigmentation and eyelash bristles after the use of five types of prostaglandin (PG) analogs.MethodsThis study included 250 eyes from 250 patie...
Enhanced Eyelashes: Prescription and Over-the-Counter Options.
Women have long strived to possess long, thick, and dark eyelashes. Prominent eyes and eyelashes are often considered a sign of beauty and can be associated with increased levels of attractiveness, co...
A Novel Convergent Synthesis of the Antiglaucoma PGF(2α) Analogue Bimatoprost.
The 17-phenyl PGF(2α) analogue bimatoprost (10a) is the most efficacious ocular hypotensive agent currently available for the treatment of glaucoma or ocular hypertension. A novel convergent synthesi...
Treatment for trichiasis through a combination of eyelash trephination and electrocautery.
Purpose: This article introduces 3-mm-deep eyelash trephination combined with electrocautery as a way to increase the success rate for treatment for trichiasis. Method: We have modified surgical...
