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In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy

2014-08-27 03:27:01 | BioPortfolio

Summary

This is a pilot study to evaluate the findings of the Reflectance Confocal Microscopy when performed in cutaneous pigmentary disorders, such as vitiligo, melasma, post-inflammatory hyper-pigmentation and hypo-pigmentation. Confocal Microscopy is a recent diagnostic technique that has been used for observation of skin conditions that affect the superficial layers of the skin.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Conditions

Vitiligo

Location

Clinical Unit for Research Trials in Skin
Boston
Massachusetts
United States
02114

Status

Recruiting

Source

Massachusetts General Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:27:01-0400

Clinical Trials [27 Associated Clinical Trials listed on BioPortfolio]

UVA 1 Phototherapy for Vitiligo

Vitiligo is a chronic acquired disease characterized by well defined white macules and patches affecting the skin. There are many treatment modalities available for vitiligo, however, none...

Narrowband UVB Treatment in Patients With Vitiligo

The study offers narrowband UVB light therapy to patients who have 5% of their body involved with vitiligo. The hypothesis is that Narrowband UVB promotes melanocyte proliferation in viti...

Determining the Tolerance of Depigmented Skin to Targeted Phototherapy Using UVB in Patients With Vitiligo

The purpose of this study is to determine if vitiligo patients develop tolerance to ultraviolet light therapy, a type of treatment available for vitiligo.

Oral Ginkgo Biloba and Narrow Band UVB in the Treatment of Vitiligo

Vitiligo is a common chronic skin disease with 1-4% prevalence. It has a significant psychosocial impact on patients and society. Different treatment modalities with variable success rat...

Audiological Disturbances in Vitiligo

The purpose of this study is to determine wether vitiligo patients have more audiological abmnormalities, than the healthy population.

PubMed Articles [54 Associated PubMed Articles listed on BioPortfolio]

Twenty-year follow-up using a postal survey of childhood vitiligo treated with narrowband ultraviolet-B phototherapy.

Vitiligo is a depigmenting skin disorder with an estimated prevalence of 1%.(1) Childhood-onset vitiligo occurs in approximately a third of all cases.(2) Early-onset childhood vitiligo tends to be a m...

Genetic Variants of INF-γ and its mRNA Expression and Inflammatory Parameters in Vitiligo Pathogenesis.

Although genetics plays an essential role in the pathogenesis of vitiligo, however, vitiligo pathogenesis is still unclear. Our aim was to investigate the role of IFN-γ expression and polymorphism in...

Reduced immunohistochemical expression of adhesion molecules in vitiligo skin biopsies.

Because defects in adhesion impairment seem to be involved in the etiopathogenesis of vitiligo, this study aimed to compare the immunohistochemical expression of several adhesion molecules in the epid...

Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib.

Existing therapies for vitiligo are limited in efficacy and can be associated with undesirable side effects. Topical Janus kinase inhibitors may offer a new therapeutic option for vitiligo.

Vitiligo patients experience barriers in accessing care.

Vitiligo is a loss of pigment occurring in approximately 0.4% to 2% of the worldwide population. The aim of this study was to determine and characterize barriers to access of care in US patients with ...

Medical and Biotech [MESH] Definitions

Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.

A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024)

A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.

A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)

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