Treatment for Word Retrieval Impairments in Aphasia
Summary
In this study the investigators are examining the effectiveness of two different speech therapy protocols for word retrieval impairments experienced by individuals with stroke-induced aphasia. One treatment involves errorless naming treatment and the other employs verbal plus gestural facilitation of word retrieval. Participants will receive one of the two treatments over several months. Before and after treatment the investigators will administer several tests and conversational samples to examine changes associated with the treatments. The investigators hypothesize that, whereas both treatments will lead to improvements in words rehearsed in therapy, communication outcomes in conversation will be broader for the verbal plus gestural protocol.
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Conditions
Stroke
Intervention
Word Retrieval Treatments for Aphasia
Location
Old Dominion University Speech and Hearing Clinic
Norfolk
Virginia
United States
23529
Status
Recruiting
Source
Old Dominion University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00764400
- Information obtained from ClinicalTrials.gov on June 14, 2012
Medical and Biotech [MESH] Definitions
Aphasia, Conduction
A type of fluent aphasia characterized by an impaired ability to repeat one and two word phrases, despite retained comprehension. This condition is associated with dominant hemisphere lesions involving the arcuate fasciculus (a white matter projection between Broca's and Wernicke's areas) and adjacent structures. Like patients with Wernicke aphasia (APHASIA, WERNICKE), patients with conduction aphasia are fluent but commit paraphasic errors during attempts at written and oral forms of communication. (From Adams et al., Principles of Neurology, 6th ed, p482; Brain & Bannister, Clinical Neurology, 7th ed, p142; Kandel et al., Principles of Neural Science, 3d ed, p848)
Echolalia
Involuntary ("parrot-like"), meaningless repetition of a recently heard word, phrase, or song. This condition may be associated with transcortical APHASIA; SCHIZOPHRENIA; or other disorders. (From Adams et al., Principles of Neurology, 6th ed, p485)
Primary Progressive Nonfluent Aphasia
A form of frontotemporal lobar degeneration and a progressive form of dementia characterized by motor speech impairment and AGRAMMATISM, with relative sparing of single word comprehension and semantic memory.
Therapies, Investigational
Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.
Paired-associate Learning
Learning in which the subject must respond with one word or syllable when presented with another word or syllable.
Clinical Trials
Real Word Effects in Phonological Treatment for Word Retrieval
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The purpose of this investigation is to further develop and test a treatment for word-finding problems in aphasia. The treatment is designed to strengthen meaning associations within categ...
Treating Intention In Aphasia: Neuroplastic Substrates
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The study investigates the possibility that levetiracetam may improve the symptoms of chronic post-stroke aphasia.
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia. A primary...
PubMed Articles
We compared the effects of two treatments for aphasic word retrieval impairments, errorless naming treatment (ENT) and gestural facilitation of naming (GES), within the same individuals, anticipating...
Identifying Behavioral Measures of Stress in Individuals with Aphasia.
PURPOSE: The current study attempts to develop valid indicators of stress in individuals with aphasia by examining the relationship between certain language variables (error frequency and word product...
BACKGROUND: . Current knowledge regarding the time course of aphasia recovery is based on observations limited to the first years after stroke. OBJECTIVE: . The authors studied long-term outcome (25 y...
Therapy for naming impairments post-stroke typically involves semantic and/or phonologically-based tasks. However, the relationship between individuals' locus of breakdown in word retrieval and their...
Implicit and Explicit Learning in Individuals with Agrammatic Aphasia.
Implicit learning is a process of acquiring knowledge that occurs without conscious awareness of learning, whereas explicit learning involves the use of overt strategies. To date, research related to...
