A Study to Investigate the Anti-Plaque Effect of AN0128 Toothpaste
Summary
The objective of this study was to evaluate the anti-plaque efficacy of the Anacor prototype dentrifice as compared to commercial control products following a single use of the dentrifice.
Description
The widespread successful use of triclosan as an anti-inflammatory and anti-bacterial agent is well documented. The standard dentrifice has demonstrated a robust anti-plaque and anti-inflammatory effect providing multiple benefits. There is a clear value to identify additional agents with the same dual action with a comparable or an enhanced level of efficacy. This study examined the anti-plaque efficacy following a single use of the prototype dentifrice.
Study Design
Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
Conditions
Dental Plaque
Intervention
Negative Control (Regular Toothpaste), Positive Control (anti-plaque/anti-bacterial toothpaste), Prototype (AN0128 Toothpaste)
Location
Concordia Research Laboratories
Cedar Knolls
New Jersey
United States
07927
Status
Completed
Source
Anacor Pharmaceuticals, Inc.
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00762151
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Gram-positive Asporogenous Rods, Regular
A group of regular rod-shaped bacteria that stain gram-positive and do not produce endospores.
Pest Control, Biological
The use of biological mechanisms, usually involving living organisms such as bacteria, for the reduction or regulation of the population of noxious, destructive, or dangerous pests. Environmental concerns have focused attention on natural forms of disease control as potentially safe and effective alternatives to chemical pesticides. This has led to increased efforts to develop control strategies that rely on natural predators and parasites or that involve genetically engineered microbial pest control agents.
United States Office Of National Drug Control Policy
A component of the Executive Office of the President established by the Anti-Drug Abuse Act of 1988. The Office establishes policies, priorities, and objectives for national DRUG AND NARCOTIC CONTROL. The goals of the program are to reduce illicit drug use, manufacturing, and trafficking, drug-related crime and violence, and drug-related health consequences.
Toothpaste
A dentifrice in paste form; usually contains binder, humectant, an abrasive, a detergent, flavoring agent and often caries preventives, anti-infective agents or other medicaments.
Social Control, Informal
Those forms of control which are exerted in less concrete and tangible ways, as through folkways, mores, conventions, and public sentiment.
Clinical Trials
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Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
Clinical research study to determine the anti-plaque efficacy of prototype dentifrices via a 4-day brushing regiment
Investigation of Dental Plaque and Gingival Index
Investigation of inhibitory effect of prototype toothpaste on dental plaque formation via modified gingival margin plaque index method.
Compare the Clinical Efficacy of Prototype Toothpastes.
Evaluate clinical efficacy of a prototype toothpaste on control of dental plaque gingival inflammation
PubMed Articles
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