Domperidone in Refractory Gastroparesis

07:58 EST 20th December 2014 | BioPortfolio


The primary objective of this study is to prescribe oral domperidone for patients with gastroparesis who have failed or suffered adverse effects from standard medical therapy.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment






Yale Digestive Diseases 40 Temple St, Suite 1A
New Haven
United States




Yale University

Results (where available)

View Results


Clinical Trials [33 Associated Clinical Trials listed on BioPortfolio]

Domperidone for Gastroparesis in Solid Organ Transplantation

The purpose of this study is to examine the clinical response to domperidone in solid organ transplant recipients with gastroparesis.

Domperidone for Refractory Gastrointestinal Disorders

The purpose of this study is to prescribe oral domperidone for subjects with gastrointestinal disorders who have failed or suffered adverse effects from standard medical treatment.

Domperidone for Relief of Gastrointestinal Disorders

The purpose of this study is to make Domperidone available to patients with gastrointestinal disorders who have failed standard therapy and who might benefit from it.

Gastroparesis Registry

The Gastroparesis Registry (GpR) is an observational study to clarify the epidemiology, natural history, clinical course, and other outcomes of gastroparesis.

Effectiveness of Domperidone to Increase Breastmilk Supply in Mothers With Low Supply

This study is testing if a medication called domperidone will help women produce more milk so that they can keep breastfeeding and not use formula. The study is also testing what dose of...

PubMed Articles [20 Associated PubMed Articles listed on BioPortfolio]

Gastroparesis: separate entity or just a part of dyspepsia?

Gastroparesis is defined by the presence of delayed gastric emptying (GE) in the absence of mechanical obstruction. Symptoms that have been attributed to gastroparesis include postprandial fullness, e...

Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers.

Abstract Background: The aim of this study was to investigate the effect of silymarin pretreatment on domperidone oral bioavailability in humans. Methods: The rats were pretreated with silymarin for 7...

Domperidone and cardiac disorders: avoid this neuroleptic.

The use of domperidone in accordance with the terms of its marketing authorisation, or off-label to increase breast milk production, exposes patients to serious cardiac risk.

Postprandial Plasma Glucose Response and Gastrointestinal Symptom Severity in Patients With Diabetic Gastroparesis.

Gastroparesis is a well-known diabetic complication. The pathogenesis is not fully understood. However, it is important to early diagnose these patients. This study evaluated the plasma glucose respon...

Report: Evaluation and comparison of different brands of domperidone tablets available in Karachi, Pakistan.

Domperidone is an anti-dopaminergic drug used for the treatment of nausea, vomiting and dyspepsia. It has also been used in Parkinson's disease. In this study, five different brands of Domeperidone ta...

Medical and Biotech [MESH] Definitions

Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.

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