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Domperidone in Refractory Gastroparesis

00:44 EDT 21st April 2014 | BioPortfolio


The primary objective of this study is to prescribe oral domperidone for patients with gastroparesis who have failed or suffered adverse effects from standard medical therapy.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment






Yale Digestive Diseases 40 Temple St, Suite 1A
New Haven
United States




Yale University

Results (where available)

View Results


Medical and Biotech [MESH] Definitions

Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Abnormal distention of the STOMACH due to accumulation of gastric contents that may reach 10 to 15 liters. Gastric dilatation may be the result of GASTRIC OUTLET OBSTRUCTION; ILEUS; GASTROPARESIS; or denervation.

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Domperidone for Gastroparesis in Solid Organ Transplantation

The purpose of this study is to examine the clinical response to domperidone in solid organ transplant recipients with gastroparesis.

Domperidone for Refractory Gastrointestinal Disorders

The purpose of this study is to prescribe oral domperidone for subjects with gastrointestinal disorders who have failed or suffered adverse effects from standard medical treatment.

Domperidone for Relief of Gastrointestinal Disorders

The purpose of this study is to make Domperidone available to patients with gastrointestinal disorders who have failed standard therapy and who might benefit from it.

Gastroparesis Registry

The Gastroparesis Registry (GpR) is an observational study to clarify the epidemiology, natural history, clinical course, and other outcomes of gastroparesis.

Effectiveness of Domperidone to Increase Breastmilk Supply in Mothers With Low Supply

This study is testing if a medication called domperidone will help women produce more milk so that they can keep breastfeeding and not use formula. The study is also testing what dose of...

PubMed Articles [17 Associated PubMed Articles listed on BioPortfolio]

Domperidone and cardiac disorders: avoid this neuroleptic.

The use of domperidone in accordance with the terms of its marketing authorisation, or off-label to increase breast milk production, exposes patients to serious cardiac risk.

A Case of Extreme Gastroparesis due to an Occult Small Cell Cancer of the Lung.

A patient with gastroparesis is presented. Ultimately the diagnosis of paraneoplastic gastroparesis due to an occult small cell cancer of the lung was made. The difficulties in the diagnostic process...

Unusual case of gastroparesis leading to severe gastromegaly with demyelinating disease as a rare cause.

Gastroparesis is an entity of symptomatic abnormal gastric emptying, with diabetes mellitus, postsurgical and idiopathic etiologies accounting for majority of the cases.

Xiangshaliujunzi Decoction for the treatment of diabetic gastroparesis: A systematic review.

To assess the current clinical evidence of the effectiveness of Xiangshaliujunzi Decoction (XSLJZD) for the treatment of diabetic gastroparesis (DGP).

Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial.

Gastroparesis remains a challenging syndrome to manage, with few effective treatments and a lack of rigorously controlled trials. Tricyclic antidepressants are often used to treat refractory symptoms...

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