Investigation of 9 Consecutive Remicade Infusions in Ankylosing Spondylitis in Austria (Study P04044)
Summary
This is a prospective, open-label, 1-arm, multicenter observational study to determine the dose and time span of infliximab between infusions for ankylosing spondylitis (AS).
Description
This study population was chosen from a non-probability sample.
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Conditions
Spondylitis, Ankylosing
Intervention
Infliximab
Status
Active, not recruiting
Source
Schering-Plough
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00725543
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Phenylbutazone
A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
Etodolac
A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
Hla-b27 Antigen
Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.
Spondylitis, Ankylosing
A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
Spondylarthropathies
Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.
Clinical Trials
Evaluation of Low Dose Infliximab in Ankylosing Spondylitis (Study P04352)(COMPLETED)
This is a randomized, double-blind, multi-center, placebo-controlled study with two parallel treatment groups (placebo and infliximab) in subjects with ankylosing spondylitis (AS) to evalu...
A Study of Infliximab (Remicade) in Patients With Ankylosing Spondylitis.
A study of the safety and efficacy of Infliximab (Remicade) versus placebo in subjects with Ankylosing Spondylitis
A Study of Infliximab (Remicade) in Patients With Ankylosing Spondylitis.
A study of the safety and efficacy of Infliximab (Remicade) versus placebo in subjects with Ankylosing Spondylitis
This trial is designed to measure improvement of hip involvement in patients with ankylosing spondylitis after receiving 4 doses of infliximab. Patients will receive infliximab 5 mg/kg (a...
Infliximab and Methotrexate in Ankylosing Spondylitis
There is a great individual variability of pharmacokinetic of infliximab in patients treated for ankylosing spondylitis (AS). Moreover, some patients have a treatment with methotrexate (MT...
PubMed Articles
What is already known about the subject: - Infliximab pharmacokinetics in ankylosing spondylitis has been described but using sparce data. - A previous work suggests that infliximab concentrations inf...
The aim of this study was to evaluate the feasibility of using power Doppler ultrasound (PDUS) to detect changes in the sacroiliac joint regions after infliximab (an anti-TNF-α blocker) treatment in...
Treatment of recurrent anterior uveitis with infliximab in patient with ankylosing spondylitis.
BACKGROUND: We describe a HLA-B27-positive Japanese man with recurrent severe anterior uveitis OU and ankylosing spondylitis (AS) who was successfully treated with infliximab. CASE: A 25-year-old HLA-...
The objective of the study is to evaluate the outcome of patients with seronegative spondyloarthritis continuing on sulphasalazine (SSZ) and methotrexate (MTX) after a short course of infliximab. Pati...
Objective: The introduction of anti- tumor necrosis factor-alpha agents (TNF-inhibitors) offered new dimensions in symptom relief and alteration of disease progression for patients with Ankylosing Spo...
