Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)
Summary
The purpose of this study is to assess the effect of creatine on slowing the worsening of HD symptoms and to assess the safety of creatine in long-term use.
Subjects will participate in sixteen (16) study visits and eighteen (18) telephone contacts over three years.
Eligible subjects will receive either up to 40 grams powdered creatine monohydrate per day or matching placebo for a total of 36 months.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Huntington's Disease
Intervention
Creatine Monohydrate (HD-02), placebo
Location
University of Alabama at Birmingham
Birmingham
Alabama
United States
35233
Status
Recruiting
Source
Massachusetts General Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00712426
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Creatine
An amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as CREATININE in the urine.
Creatine Kinase
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Guanidinoacetate N-methyltransferase
This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanidinoacetate to CREATINE.
Creatine Kinase, Mb Form
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
Creatine Kinase, Mm Form
An isoenzyme of creatine kinase found in the MUSCLE.
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