Platelet Transfusion in Acute Intracerebral Hemorrhage
Summary
- To prove whether use of antiplatelet agents results into a rapid enlargement of hematoma after onset of acute intracerebral hemorrhage.
- To prove the efficacy and safety of platelet transfusion for prevention of hematoma growth in patients who were stricken by acute intracerebral hemorrhage while being on antiplatelet medication.
Description
- Hematoma growth is a well-known powerful determinant of mortality and poor outcome after intracerebral hemorrhage.
- Some observations suggest that previous use of antiplatelet agents associates with rapid hematoma enlargement and poor outcome after cerebral hemorrhage.
- Immediate platelet transfusion for such patients may prevent hematoma growth but also cause thromboembolic complications.
Study Design
Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Conditions
Intracerebral Hemorrhage
Intervention
platelets
Location
Department of Neurology, Oulu University Hospital
Oulu
Finland
90029 OYS
Status
Recruiting
Source
University of Oulu
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00699621
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Platelet Adhesiveness
The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.
Retrobulbar Hemorrhage
Hemorrhage within the orbital cavity, posterior to the eyeball.
Eye Hemorrhage
Intraocular hemorrhage from the vessels of various tissues of the eye.
Pneumocephalus
Presence of air or gas within the intracranial cavity (e.g., epidural space, subdural space, intracerebral, etc.) which may result from traumatic injuries, fistulous tract formation, erosions of the skull from NEOPLASMS or infection, NEUROSURGICAL PROCEDURES, and other conditions.
Platelet-rich Plasma
A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.
Clinical Trials
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Simvastatin For Intracerebral Hemorrhage Study
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Antihypertensive Treatment in Acute Cerebral Hemorrhage
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rFVIIa in ICH in Patients Treated With Anticoagulants or Anti-Platelets
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PubMed Articles
International Epidemiology of Intracerebral Hemorrhage.
Intracerebral hemorrhage is the second most common subtype of stroke. In recent decades our understanding of intracerebral hemorrhage has improved. New risk factors have been identified; more knowledg...
Intracranial hemorrhage : Diagnosis, prognosis, acute treatment and secondary prophylaxis.
Given the number of studies that have investigated the subject of intracerebral hemorrhage, there are still many research questions unanswered, including prevention and treatment of progressive hemorr...
Plasma adiponectin as an independent predictor of early death after acute intracerebral hemorrhage.
Hyperadiponectinemia or hypoadiponectinemia is associated with different diseases. There is a paucity of data on circulating plasma adiponectin concentrations in human intracerebral hemorrhage (ICH)....
Hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage.
PURPOSE: To evaluate hemodynamic effects of mannitol infusion in patients with acute intracerebral hemorrhage. METHODS: Thirty patients with acute intracerebral hemorrhage were enrolled. Transcranial...
Relapsing non-traumatic intracerebral hemorrhage: study of 28 patients.
BACKGROUND AND OBJETIVE: To characterize the clinical factors and prognosis and identify determinants of hemorrhage recurrence (HCR) in patients with acute non-traumatic intracerebral hemorrhage.
