Prediction of the Risk of Placental Vascular Pathology and Venous Thromboembolic Disease
Summary
Venous thromboembolic (VTE) disease is the first cause of maternal mortality in the world. Some other pregnancy pathologies called Placental Vascular Pathologies (PVP) are linked to VTE by biological thrombophilia and are the principal cause of perinatal mortality. the identification of predictive factors of risk of occurrence or recurrence of two pathologies could enable us to propose an appropriate monitoring of patients at risk.
Description
Main aim: To evaluate echographic, doppler and biological markers in a prospective manner as a potential predictive factor of risk of PVP and VTE.
Study Design
Observational Model: Cohort, Time Perspective: Prospective
Conditions
Placental Vascular Pathologies
Location
Service d'Hématologie - CHU de Nîmes
Nîmes
France
30000
Status
Recruiting
Source
Centre Hospitalier Universitaire de Saint Etienne
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00695942
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Placental Lactogen
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.
Placental Function Tests
Methods used for the assessment of placental function.
Placental Extracts
Extracts prepared from placental tissue; they may contain specific but uncharacterized factors or proteins with specific activities.
Placental Hormones
Hormones produced by the placenta include CHORIONIC GONADOTROPIN, and PLACENTAL LACTOGEN as well as steroids (ESTROGENS; PROGESTERONE), and neuropeptide hormones similar to those found in the hypothalamus (HYPOTHALAMIC HORMONES).
Maternal-fetal Exchange
Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.
Clinical Trials
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PubMed Articles
Placental Magnetic Resonance Imaging in Monochorionic Twin Pregnancies.
Abstract Objective: Twin-twin transfusion syndrome (TTTS) is a severe complication of monochorionic pregnancies. Placental hydrops might be a marker for TTTS. The purpose of this study was to evalua...
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Preeclampsia (PE) and vascular intra-uterine growth restriction (vIUGR) are two pathological obstetrical conditions originating from placental dysfunction. Recently, methylation changes at the placent...
Abstract Aim: To determine the association, if any, between placental architecture findings assessed ultrasonographically at 22 and 36 weeks and placental histology. Methods: There was prospective rec...
Both vasculogenesis and angiogenesis occur during normal placental vascular development. Additionally, the placenta undergoes a process of vascular mimicry (pseudo-vasculogenesis) where the placental...
