Resistant Starch on Glucose and Insulin Sensitivity in Individuals With Type 2 Diabetes
Summary
This study will test the effects of resistant starch type 4 on blood sugar and hunger in adults with Type 2 diabetes.
Description
To measure the blood glucose response, after an overnight fast, blood samples will be collected before eating and 15, 30, 45, 60, 90, and 120 minutes after eating each bar. The incremental area under the curve was used to calculate glycemic index. The investigators will also measure the second meal effect by measuring the metabolic response (glucose, insulin, and gut hormones) after a standardized lunch two hours following the first assessment.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Supportive Care
Conditions
Hyperglycemia
Intervention
Resistant Starch Type 4-Raw, Resistant Starch Type 4-Raw, Resistant Starch Type 4-Cooked, Resistant Starch Type 4-Cooked, Shredded Wheat
Location
Kansas State Univerity: Department of Human Nutrition
Manhattan
Kansas
United States
66506
Status
Completed
Source
Kansas State University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00691249
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Electrophoresis, Starch Gel
Electrophoresis in which a starch gel (a mixture of amylose and amylopectin) is used as the diffusion medium.
Tuberculosis, Multidrug-resistant
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
Starch Phosphorylase
An enzyme of the PHOSPHORYLASES family that catalyzes the degradation of starch, a mixture of unbranched AMYLOSE and branched AMYLOPECTIN compounds. This phosphorylase from plants is the counterpart of GLYCOGEN PHOSPHORYLASE in animals that catalyzes the reaction of inorganic phosphate on the terminal alpha-1,4-glycosidic bond at the non-reducing end of glucans resulting in the release of glucose-1-phosphate.
Extensively Drug-resistant Tuberculosis
Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
Amylose
An unbranched glucan in starch.
Clinical Trials
Effect of Resistant Starch Type 4 on Glycemia and Insulin Sensitivity in Young Adults
This study tested the effects of resistant starch type 4 on blood sugar and hunger in young adults with Type 2 diabetes.
Effects of Hi-maize Resistant Starch on Insulin Sensitivity
The purpose of this study is to determine the effects of a dietary fiber, resistant starch, on insulin sensitivity. Low insulin sensitivity is a risk factor for some diseases including ty...
Comparison of Different Types of Resistant Starch
This study is to determine whether different types of resistant starch have different effects on blood glucose in healthy adults.
Resistant Starch on Glycemic Response in Older Adults
The purpose of this study was to determine how blood glucose changes after eating energy bars containing resistant starch type 4 compared with bars made with puffed wheat in healthy older...
Resistant Starch Insulin Sensitivity Trial
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PubMed Articles
The aim of the study was the production of resistant starch from taro (Colocasia esculenta L. Schott) corm and determination of its effects on health by in vitro methods. Starch was isolated from taro...
Effects of β-Amylolysis on the Resistant Starch Formation of Debranched Corn Starches.
Retrograded amylose is resistant to digestion by amylolytic enzymes, which is known as resistant starch type III (RS3). In this study we investigated the effect of β-amylase hydrolysis on the formati...
Acetylated retrograded starch is one of the forms of resistant starch (RS3/4). Apart from the known resistance to amylolysis, it is characterized by the capability to form viscous pastes. Properties o...
C-type starch, which is a combination of both A-type and B-type crystal starch, is usually found in legumes and rhizomes. We have developed a high-amylose transgenic line of rice (TRS) by antisense RN...
Resistant-starch formation in high-amylose maize starch during Kernel development.
The objective of this study was to understand the resistant-starch (RS) formation during kernel development of a high-amylose maize, GEMS-0067 line. The RS content of the starch, determined using AOAC...
