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Diaphragm Plication in Adults With Phrenic Nerve Paralysis

2014-07-24 14:17:30 | BioPortfolio

Summary

The purpose of the study is to investigate the impact of unilateral or bilateral diaphragm plication in a prospective randomised controlled way on symptoms, pulmonary function including gas exchange, respiratory muscle strength, exercise capacity and breathing during sleep in patients with proven uni- or bilateral phrenic nerve paralysis present for at least 1 year without any evidence of spontaneous recovery.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Phrenic Nerve Paralysis

Intervention

diaphragm plication 6 months after inclusion, diaphragm plication at time of inclusion

Location

University Hospital Gasthuisberg Divisionof Pulmonology
Leuven
Belgium
3000

Status

Recruiting

Source

Katholieke Universiteit Leuven

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:17:30-0400

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PubMed Articles [15838 Associated PubMed Articles listed on BioPortfolio]

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Thoracoscopic diaphragm plication.

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Medical and Biotech [MESH] Definitions

A state of unconsciousness as a complication of diabetes mellitus. It occurs in cases of extreme HYPERGLYCEMIA or extreme HYPOGLYCEMIA as a complication of INSULIN therapy.

A congenital abnormality characterized by the elevation of the DIAPHRAGM dome. It is the result of a thinned diaphragmatic muscle and injured PHRENIC NERVE, allowing the intra-abdominal viscera to push the diaphragm upward against the LUNG.

The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.

Soft tissue formed mainly by the pelvic diaphragm, which is composed of the two levator ani and two coccygeus muscles. The pelvic diaphragm lies just below the pelvic aperture (outlet) and separates the pelvic cavity from the PERINEUM. It extends between the PUBIC BONE anteriorly and the COCCYX posteriorly.

The motor nerve of the diaphragm. The phrenic nerve fibers originate in the cervical spinal column (mostly C4) and travel through the cervical plexus to the diaphragm.

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