Optimal Timing of Intrauterine Insemination (IUI) When Utilizing Superovulation Combined With GnRH Antagonists
Summary
The timing of IUI following ovulation induction has been the subject of many studies and a consensus has developed that a single insemination approximately thirty-six hours after ovulation induction is sufficien. The introduction of GnRH antagonists preventing a premature LH surge and early ovulation has added a new dimension to fertility treatment. It allows greater accuracy in predicting the timing of ovulation and has been shown to be at least as effective, if not more effective, as ovarian stimulation without antagonists. We hypothesize that by utilizing GnRH antagonists we can increase pregnancy rates during IUI by timing the IUI as close as possible to the moment of ovulation guaranteeing the highest and freshest concentration of motile spermatozoa in the fallopian tube at the time the oocyte is released from the ovary. We therefore propose a randomized open three arm prospective trial utilizing superovulation with GnRH antagonists whereby the IUI is timed to take place 36, 42 or 48 hours after ovulation induction.
Study Design
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Infertility
Intervention
Intrauterine Insemination
Location
HaEmek Medical Center
Afula
Israel
18101
Status
Recruiting
Source
HaEmek Medical Center, Israel
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00675142
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Insemination, Artificial, Heterologous
Human artificial insemination in which the semen used is that of a man other than the woman's husband.
Insemination, Artificial, Homologous
Human artificial insemination in which the husband's semen is used.
Intrauterine Device Expulsion
Spontaneous loss of INTRAUTERINE DEVICES from the UTERUS.
Infertility
Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.
Intrauterine Device Migration
The shifting in position or location of an INTRAUTERINE DEVICE from its original placement.
Clinical Trials
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GnRH Agonist and Intrauterine Insemination
The aim of this study is to assess whether GnRH agonist administration in the luteal phase improves pregnancy outcome in intrauterine insemination (IUI) cycles.
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PubMed Articles
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Citation Subit M, Gantt P, Broce M, Seybold DJ, Randall G. Endometriosis-associated infertility: double intrauterine insemination improves fecundity in patients positive for antiendometrial antibodies...
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