Antibiotic Study for Dental Implants
Summary
This study is for people at least 21 years old who have signs of problems, like swollen gums and shrinking bones, by dental implants.
Description
At Visit 1, the dentist will:
- do an oral exam
- ask some questions
- decide if the person qualifies for being in the study
- make an appointment for Visit 2 if they qualify
At Visit 2 (Baseline), the dentist will:
- do a special cleaning of the implants
- examine the whole mouth
- collect some fluid
- take x-rays
- put the people into one of two groups (taking into account whether or not they smoke)
1. one group will have the study antibiotic put on all the areas in their mouth with gum problems
2. the other group will not receive the antibiotic At Visit 3 (about a month later), only fluid samples will be collected.
At Visit 4 (about 3 months later), the dentist will:
- collect fluid samples
- examine the whole mouth
- apply the antibiotic again for people in that group
At Visit 5 (about 6 months later), the dentist will:
- collect fluid samples
- examine the whole mouth
- take x-rays
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Periodontitis
Intervention
Minocycline HCl
Location
JJCPPW Investigational Site
Aurora
Colorado
United States
80012
Status
Completed
Source
Johnson & Johnson Consumer & Personal Products Worldwide
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00662532
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Periodontitis
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Chronic Periodontitis
Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.
Aggressive Periodontitis
Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Minocycline
A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.
Capnocytophaga
A gram-negative gliding bacterium isolated from the oral cavity. It is a pathogen often causing PERIODONTITIS.
Clinical Trials
The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease
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PubMed Articles
The present study evaluated the effects of systemic minocycline on clinical and biochemical parameters of chronic periodontitis, which is a common inflammatory disorder of the periodontium initiated b...
A case of anaphylaxis to oral minocycline.
Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. To date, there has been only one case report of anaphylaxis to minocycline. We report here...
Effects of minocycline on Na(+) currents in rat dorsal root ganglion neurons.
Minocycline is an inhibitor of microglial activation and proliferation. Minocycline suppresses pain-related behaviors in many different pain states, which correlates closely with its inhibition of mic...
Available data indicate that minocycline, an antibiotic of the tetracycline family, has cytoprotective properties due to a direct interaction with mitochondria. Yet, the data in the case of isolated m...
Pharmacokinetics and tissue distribution of minocycline hydrochloride in horses.
Objective-To determine the pharmacokinetics and tissue distribution of minocycline in horses. Animals-5 healthy Thoroughbred mares for the pharmacokinetic experiment and 6 healthy Thoroughbred mares f...
