Adapalene Gel 0.3% Versus Tretinoin Cream 0.05% for Treatment of Photodamage
Summary
The primary purpose of this study is to compare the efficacy of adapalene (Differin®) gel 0.3% and tretinoin 0.05% emollient cream for the treatment of signs of photodamage, with tolerability assessment as a secondary objective.
Description
Same as above.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Conditions
Skin Aging
Intervention
adapalene gel, 0.3%, tretinoin 0.05% emollient cream
Location
University of Michigan Department of Dermatology
Ann Arbor
Michigan
United States
48109
Status
Completed
Source
Galderma Laboratories, L.P.
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00647556
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Tretinoin
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
Skin Aging
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
Plasma Skin Regeneration
A cosmetic technique that uses PLASMA GASES in therapeutic treatment to help achieve skin REJUVENATION or REGENERATION and delay SKIN AGING.
Ice Cream
A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.
Flurandrenolone
A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
Clinical Trials
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PubMed Articles
Background: Clinical studies as well as histologic data maintain that tretinoin improves the appearance of photodamage; however, the long-term benefits of tretinoin 0.02% in moderate to severe photoda...
Vitamin A and its derivatives (commonly termed retinoids) are widely used in topical anti-aging products. Certain retinoids such as retinol and its esters are available without a prescription, while o...
Background: A hydroquinone (HQ) skin care system has been designed for use in conjunction with nonsurgical procedures. Objective: The authors evaluate the efficacy of this system plus tretinoin for im...
Effect of Aqueous Cream BP on Human Stratum Corneum In Vivo.
Summary Background - Aqueous Cream BP is widely prescribed to eczema patients to relieve skin dryness. The formulation contains sodium lauryl sulphate (SLS) - a chemical that is a known skin irritant...
Emollient Molecule Effects on the Drying Stresses in Human Stratum Corneum.
SUMMARY Background: Emollient molecules are widely used in skin care formulations to improve skin sensory properties and to alleviate dry skin but little is understood regarding their effects on skin...
