Advertisement
Advertise here Publish your press releases here Sponsor BioPortfolio
Follow us on Twitter Sign up for daily news and research emails Contributors wanted

Stem Cells and Tibial Fractures

19:05 EDT 25th July 2014 | BioPortfolio

Summary

The aim of this trial is to determine the safety and tolerability of expanded autologous progeny of an adult CD34+ (haemopoietic) stem cell subset when infused directly into the tibial artery of patients with recent tibial fracture. The trial will also seek to determine clinical improvement or deterioration by measurement of clinical parameters such as, length of time to union of the fracture, changes in bone mineral density, improvements in pain scores (VAS), functional ability (TUGT) and IPAQ scores.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Tibial Fractures

Intervention

CD34+ haemopoietic stem cells

Location

Charing Cross Hospital
London
United Kingdom
W6 8RF

Status

Not yet recruiting

Source

Imperial College London

Results (where available)

View Results

Links

Clinical Trials [1280 Associated Clinical Trials listed on BioPortfolio]

Autologous Implantation of Mesenchymal Stem Cells for the Treatment of Distal Tibial Fractures

Mesenchymal stem cells are found in bone marrow, and have the ability to differentiate into different tissue types. The primary objective of the study is to examine the safety of using suc...

TRial to Evaluate UltraSound in the Treatment of Tibial Fractures

The purpose of this study is to determine the effect of low-intensity, pulsed ultrasound on tibial fractures treated with intramedullary nailing.

Use of a Reinforced Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures

Case series of tibial plateau fractures using Norian Drillable.

A Phase I/II Safety and Tolerability Dose Escalation Study of Autologous Stem Cells to Patients With Liver Insufficiency

This is a prospective dose escalation study of the administration of adult human stem cells in patients with end stage liver failure. Successive groups of two patients will receive ascendi...

Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients

The objective of the study is to determine the efficacy of brain transplants of CD34+ stem cells obtained from peripheral blood of patients in the treatment of chronic stroke patients.

PubMed Articles [18464 Associated PubMed Articles listed on BioPortfolio]

Treatment of open pediatric tibial fractures by external fixation versus flexible intramedullary nailing: a comparative study.

Tibial fractures are the third most common pediatric long-bone fracture after forearm and femoral fractures. Approximately 50% of pediatric tibial fractures occur in the distal third of the tibia. Thi...

Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation.

The number of infused CD34+cells (CD34+i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with...

Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes.

Immune-mediated bone marrow failure syndromes (BMFS) are characterized by ineffective marrow haemopoiesis and subsequent peripheral cytopenias. Ineffective haemopoiesis is the result of a complex marr...

Generation of multipotent early lymphoid progenitors from human embryonic stem cells.

During human embryonic stem cell (ESC) hematopoietic differentiation, the description of the initial steps of lymphopoiesis remains elusive. Using a two-step culture procedure we identified two origin...

Molecular Profiling of Single Sca-1(+)/CD34(+,-) Cells-The Putative Murine Lung Stem Cells.

Murine bronchioalveolar stem cells play a key role in pulmonary epithelial maintenance and repair but their molecular profile is poorly described so far. In this study, we used antibodies directed aga...

Medical and Biotech [MESH] Definitions

Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.

Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.

The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.

More From BioPortfolio on "Stem Cells and Tibial Fractures"

Search BioPortfolio:

Relevant Topics

Stem Cells · Latest News · Clinical Trials · Research · Drugs · Reports · Corporate
Track and monitor developments in stem cell research and commercial development.  Follow the tabs above to read the latest global news, research, clinical trials on stem cells and follow companies active in the stem cell industry.  BioPort...

Anesthesiology · Latest News · Clinical Trials · Research · Drugs · Reports · Corporate
An anesthesiologist (US English) or anaesthetist (British English) is a physician trained in anesthesia and perioperative medicine. Anesthesiologists are physicians who provide medical care to patients in a wide variety of (usually acute) situations....

Advertisement
Advertisement