A Study to Characterize Epidemiology, Clinical and Genetic Features of Kallmann Syndrome in Finland
Summary
Objective is to characterize epidemiology, clinical and genetic features of Kallmann syndrome in Finland.
Description
Kallmann syndrome is comprised of idiopathic hypogonadotropic hypogonadism and anosmia (inability to smell). Associated phenotypes may include cryptorchidism, microphallus, bone deformations, mirror movements, hearing loss and infertility. Objective is to characterize epidemiology, clinical and genetic features of Kallmann syndrome in Finland.
Study Design
Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Kallmann Syndrome
Intervention
Short withdrawal of testosterone, gonadotropins or estrogenic compounds (see below)
Location
Hospital for Children and Adolescents, Helsinki University Central Hospital
Helsinki
Finland
00029 HUCH
Status
Enrolling by invitation
Source
Hospital for Children and Adolescents, Finland
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00623116
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Substance Withdrawal Syndrome
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
Testosterone Congeners
Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.
Gonadotropins
Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.
Danazol
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Dihydrotestosterone
A potent androgenic metabolite of TESTOSTERONE. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to ESTRADIOL therefore DHT is considered a pure androgenic steroid.
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PubMed Articles
The Kallmann syndrome is a very rare congenital association of gonadotropin-releasing hormone deficiency and hyposmia or anosmia. Clinically it is characterized by low serum concentrations of testoste...
The endocrine disruption associated with alcohol (ethanol) abuse in both males and females is widely recognized. Ethanol intoxication and withdrawal in males results in significant reductions in andro...
Seven estrogenic compounds-estrone (E1), 17beta-estradiol (E2), 17alpha-ethynylestradiol (EE2), diethylstilbestrol (DES), nonylphenol (NP), octylphenol (OP), and bisphenol A (BPA)-in sediments, surfac...
Late-onset hypogonadism in middle-aged and elderly men.
To the Editor: Wu et al. (July 8 issue)(1) propose a new definition of late-onset hypogonadism in men that is based on a symptom score in combination with a testosterone threshold. In his editorial, B...
Late-onset hypogonadism in middle-aged and elderly men.
To the Editor: Wu et al. (July 8 issue)(1) propose a new definition of late-onset hypogonadism in men that is based on a symptom score in combination with a testosterone threshold. In his editorial, B...
