Evaluation of the Extension at Community Level of Safe Male Circumcision (ANRS 12126 ORANGE FARM 2)
Summary
This study is aimed at demonstrating whether or not Male Circumcision can be used as an effective public health prevention tool that will have an impact on HIV prevalence in the South African population.
Description
A randomized, controlled trial (ANRS 1265) conducted in Orange Farm (South Africa) has demonstrated that male circumcision (MC) can reduce the risk of HIV acquisition by more than 50% among young men. This result has been confirmed by two similar studies conducted in Uganda and in Kenya.
Giving these findings, the next logical step is to demonstrate whether or not MC can be used as an effective public health prevention tool that will have an impact on HIV in populations as well as among individuals.
This research study aims to establish a MC intervention in the community where the first randomized controlled trial of the impact of MC on men's risk of acquiring HIV infection was carried out in order to evaluate its impact on:
1. knowledge, attitudes and practice regarding MC
2. existing means of prevention (sexual behavior change, condom use, STI treatment-seeking behavior and VCT (voluntary counseling and testing) attendance)
3. the spread of HIV and HSV-2
This research will be carried out over a period of 60 months and will have three major components: (1) the delivery of the intervention, (2) quantitative studies (cross-sectional surveys), and (3) qualitative studies.
Study Design
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Conditions
HIV Infections
Intervention
Male Circumcision
Location
Male Circumcision Centre
Orange Farm
Johannesburg
South Africa
Status
Recruiting
Source
French National Agency for Research on AIDS and Viral Hepatitis
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00623051
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Circumcision, Male
Excision of the prepuce of the penis (FORESKIN) or part of it.
Tuberculosis, Male Genital
MYCOBACTERIUM infections of the male reproductive tract (GENITALIA, MALE).
Genital Diseases, Male
Pathological processes involving the male reproductive tract (GENITALIA, MALE).
Male Urogenital Diseases
Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).
Encephalitis, Viral
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
Clinical Trials
Effect of Male Circumcision on HIV Incidence (ANRS 1265)
Observational studies suggest that male circumcision may provide protection against HIV-1 infection. A randomized, controlled, intervention trial was conducted in a general population of S...
Feasibility, Acceptability, and Safety of Neonatal Male Circumcision in Lusaka, Zambia
In this study of neonatal male circumcision (NMC), the investigators will examine acceptability of among parents, feasibility of training providers and implementing services in various cli...
The Shang Ring: A Novel Male Circumcision Device for HIV Prevention
The purpose of this study is to evaluate the Shang Ring, a novel Chinese device for voluntary medical male circumcision, in order to improve the provision of male circumcision services for...
Phase II Trial to Evaluate the Safety and Efficacy of the Dry Circumcision Method
The objective of this clinical investigation is to provide the first and preliminary clinical data to study the safety and efficacy of male circumcision where the dry circumcision method i...
Background: Novel HIV prevention approaches are urgently needed in Botswana and elsewhere in sub-Saharan Africa. Although adult male circumcision has been shown to reduce the acquisition o...
PubMed Articles
Male circumcision: Africa and beyond?
PURPOSE OF REVIEW: Male circumcision has become an important component of HIV prevention strategies in Africa. Results of recent trials have renewed interest in this ancient procedure and its potentia...
: The efficacy of male circumcision for HIV prevention over 2 years has been demonstrated in three randomized trials, but the longer-term effectiveness of male circumcision is unknown.
Risk compensation associated with male circumcision has been a concern for male circumcision scale-up programs. Using posttrial data collected during 2007-2011 on 2,137 male circumcision trial partici...
How low can you go: the impact of a modestly effective HIV vaccine compared with male circumcision.
OBJECTIVE: The first evidence of modest effectiveness of an HIV vaccine was demonstrated by the RV144 trial in Thailand in 2009. Although promising, this vaccine has largely been dismissed because it...
The ShangRing device for simplified adult circumcision.
Adult male circumcision reduces HIV transmission through vaginal intercourse and is being promoted in areas where HIV is widespread. Conventional surgical circumcision involves suturing and thus requi...
