Advertisement
Advertise here Publish your press releases here Sponsor BioPortfolio
Follow us on Twitter Sign up for daily news and research emails Contributors wanted

Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates

19:20 EDT 30th July 2014 | BioPortfolio

Summary

The purpose of this study is to investigate the effects of intravenous furosemide on cardio-respiratory performance in neonates receiving a packed red blood cell (PRBC) transfusion who are considered at high risk of volume overload.

Description

Red cell transfusion is a very common practice in neonates, particularly in preterm infants. It has been estimated that approximately 300,000 neonates undergo transfusions annually. The decision to administer a blood transfusion to a sick anemic neonate is made after consideration of multiple clinical factors, including: poor weight gain, oxygenation failure, and recurrent apnea and bradycardia. These decisions are also influenced by physician preferences. For many years, furosemide has been used routinely by physicians during and after blood transfusions in neonates and other age groups. The rationale behind this common practice is to reduce the vascular overload that may be imposed by the additional blood volume delivered during transfusion. This belief, however, lacks the support of scientific clinical evaluation.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Lung Disease

Intervention

Furosemide, Saline

Location

The Hospital for Sick Children
Toronto
Ontario
Canada
M5G 1X8

Status

Recruiting

Source

The Hospital for Sick Children

Results (where available)

View Results

Links

Clinical Trials [785 Associated Clinical Trials listed on BioPortfolio]

Prevention of Contrast-Induced Nephropathy

Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram. The investigators hypothesiz...

Inhaled Furosemide Versus Placebo for Acute Viral Bronchiolitis in Hospitalized Infants

We hypothesize that inhaled Furosemide will be an effective treatment in infants with acute bronchiolitis.

Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure

The purpose of this study is to determine whether continuing or discontinuing furosemide (a diuretic) on the day of elective noncardiac surgery for those who take furosemide on a chronic b...

Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers

In this study the gender specificity of the effects of furosemide in female and male volunteers will be investigated. The healthy volunteers receive 1. furosemide and 2. aminohippurate sod...

Furosemide Inhalation in Dyspnea of Mustard Gas Exposed Patients

to assess the efficacy of inhaled furosemide in mustard gas exposed patients with acute respiratory failure

PubMed Articles [18587 Associated PubMed Articles listed on BioPortfolio]

Furosemide diminishes (18)F-fluoroethylcholine uptake in prostate cancer in vivo.

(18)F-Fluoroethylcholine ((18)F-FECh) is excreted via the urinary system with high activity accumulation in the urinary bladder. Furosemide and oral hydration can be administered concomitantly to redu...

The use of furosemide in critically ill trauma patients: A retrospective review.

Excessive fluid administration in critically ill post-traumatic patients is common and is associated with poorer outcomes. Once resuscitation is complete; however, assisted diuresis with furosemide is...

Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy.

Nephropathy is one of the complications of diabetes mellitus in human and experimental animals. There are various pathological renal remodeling processes leading to diabetic nephropathy because of the...

Repeated Administration of Bone Marrow-Derived Cells Prevents Disease Progression in Experimental Silicosis.

Background/Aims: Bone marrow-derived cells (BMDCs) reduced mechanical and histologic changes in the lung in a murine model of silicosis, but these beneficial effects did not persist in the course of l...

Therapeutic effects of compound hypertonic saline on rats with sepsis.

Sepsis is one of the major causes of death and is the biggest obstacle preventing improvement of the success rate in curing critical illnesses. Currently, isotonic solutions are used in fluid resuscit...

Medical and Biotech [MESH] Definitions

A diffuse parenchymal lung disease caused by accumulation of inhaled CARBON or coal dust. The disease can progress from asymptomatic anthracosis to massive lung fibrosis. This lung lesion usually occurs in coal miners, but can be seen in urban dwellers and tobacco smokers.

A genus of HALOBACTERIACEAE distinguished from other genera in the family by the presence of specific derivatives of TGD-2 polar lipids. Haloarcula are found in neutral saline environments such as salt lakes, marine salterns, and saline soils.

A family of gram-negative, moderately halophilic bacteria in the order Oceanospirillales. Members of the family have been isolated from temperate and Antarctic saline lakes, solar salt facilities, saline soils, and marine environments.

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.

A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.

More From BioPortfolio on "Using Furosemide to Prevent Fluid Overload During Red Blood Cell Transfusion in Neonates"

Search BioPortfolio:
Advertisement

Relevant Topics

Cardiology
Latest News Clinical Trials Research Drugs Reports Corporate
Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Blood
Latest News Clinical Trials Research Drugs Reports Corporate
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Advertisement