The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks
Summary
Dexamethasone is a commonly used steroid. This medication has been used for many years by physicians for many different indications. Recent articles, multiple case reports, and experience at this institution have indicated that dexamethasone successfully prolongs the effective duration of local anesthetics for regional blocks. This can cause a significant reduction in postoperative pain and the decreased need for postoperative narcotics. Although other adjuncts can be used for prolonging nerve blocks, epinephrine causes local vasoconstriction which can cause ischemia and nerve damage in a large nerve such as the sciatic nerve.Dexamethasone will not cause this problem and yet could prolong the duration of a sciatic nerve block. Therefore, the goal of this study is to prospectively evaluate the effectiveness of dexamethasone, both locally through the nerve block and systemically via IV administration, in prolonging the effective duration of local anesthetics when used in sciatic nerve blocks.
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Conditions
Total Knee Arthroplasty
Intervention
Ropivacaine, Dexamethasone, Dexamethasone, Normal Saline
Location
Loma Linda University Medical Center
Loma Linda
California
United States
92354
Status
Recruiting
Source
Loma Linda University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00616603
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid.
Arthroplasty, Replacement, Knee
Replacement of the knee joint.
Dexamethasone Isonicotinate
An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.
Glucocorticoid-induced Tnfr-related Protein
A member of the TNF receptor family that was initially identified as a DEXAMETHASONE-induced protein from a T-CELL line. It may play a role in regulating APOPTOSIS and modulating immune response by T-lymphocytes. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Arthroplasty, Replacement
Partial or total replacement of a joint.
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