Vaginal Infection Study
Summary
This study will evaluate the efficacy and safety of a vaginal product compared with that of other vaginal products and placebo in the treatment of vaginal infections.
Study Design
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Vulvovaginitis
Intervention
clindamycin phosphate/butoconazole nitrate, clindamycin phosphate, butoconazole nitrate
Location
Jefferson Clinic, PC
Birmingham
Alabama
United States
35233
Status
Completed
Source
KV Pharmaceutical Company
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00616330
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Nitrate Reductase (nadh)
An NAD-dependent enzyme that catalyzes the oxidation of nitrite to nitrate. It is a FLAVOPROTEIN that contains IRON and MOLYBDENUM and is involved in the first step of nitrate assimilation in PLANTS; FUNGI; and BACTERIA. It was formerly classified as EC 1.6.6.1.
Nitrate Reductase (nad(p)h)
An iron-sulfur and MOLYBDENUM containing FLAVOPROTEIN that catalyzes the oxidation of nitrite to nitrate. This enzyme can use either NAD or NADP as cofactors. It is a key enzyme that is involved in the first step of nitrate assimilation in PLANTS; FUNGI; and BACTERIA. This enzyme was formerly classified as EC 1.6.6.2.
Nitrate Reductase (nadph)
An enzyme that catalyzes the oxidation of nitrite to nitrate in the presence of NADP+. It is a FLAVOPROTEIN that contains IRON and MOLYBDENUM. This enzyme was formerly classified as EC 1.6.6.3 and should not be confused with the enzyme NITRATE REDUCTASE (NAD(P)H).
Nitrate Reductase
An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contains IRON and MOLYBDENUM.
Nicorandil
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
Clinical Trials
This study will evaluate the efficacy and safety of a vaginal product compared with that of another vaginal product in the treatment of vaginal infections.
Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea
The purpose of this study is to determine whether Clindamycin Phosphate 1.2% And Tretinoin 0.025% Gel are effective and safe in the treatment of papulopustular rosacea.
This is a single-blind (blinded expert grader) study that will enroll 25-30 healthy volunteers without facial acne. On 1 side of the face, the subject will apply 1 of the 2 test products,...
The concept behind our study was to combine an effect of antibiotic and anti-inflammatory agents for a more efficient acne therapy directed at the factors involved in the pathophysiology o...
Efficacy of Potassium Nitrate Solution in Reducing Dentinal Hypersensitivity
An exploratory study investigating the direct application of potassium nitrate solutions of different concentrations in reducing dentine hypersensitivity.
PubMed Articles
Combination therapy addressing multiple pathogenic factors should be used to achieve optimal outcomes in treating acne. The following study demonstrated both safety and efficacy of fixed-dose clindamy...
Draft Genome Sequence of the Nitrate- and Phosphate-Accumulating Bacillus sp. Strain MCC0008.
Here, we report the draft genome sequence of the nitrate- and phosphate-accumulating Bacillus sp. strain MCC0008, isolated from a consortium enriched from municipal sewage in nitrate broth (HiMedia M4...
A passive sampler device for the kinetic accumulation of nitrate (NO3(-)) and phosphate (HPO4(2-)) in water was developed and calibrated. The sampler incorporates an ion-exchange disk as the receiving...
Porous zirconia monolith modified with clindamycin phosphate (CLIP-ZM) was used as chiral stationary phase (CSP) to separate a set of six acidic and basic chiral compounds in capillary electrochromato...
Clindamycin in a commonly used antibiotic, considered safe for oral, intravenous and intra-arterial use. We present a case of a patient that received an inadvertent injection clindamycin 600 mg in 4 m...
