Moderate Mitral Regurgitation in CABG Patients

04:06 EDT 2nd July 2015 | BioPortfolio

Summary

Background:

The presence of a mild to moderate ischemic mitral regurgitation (IMR) results in a significantly reduced long-term survival and increased hospitalizations for heart-failure. The benefit of adding mitral valve surgery to coronary artery by-pass surgery (CABG) is well documented in the combination of coronary artery disease and severe MR. On the other hand, it is clinical practice to refrain from repairing the mitral valve in those CABG cases where the IMR is mild to moderate. However, there are no conclusive data available to support this principle. The existing studies are small, retrospective, and the results contradictive. The need for a prospective randomized trial has frequently been proposed and discussed, however, to the best of our knowledge, such a study has not yet commenced.

Study design:

The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) Trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to either CABG alone or CABG plus mitral valve correction.

Implication:

If correction of moderate MR in CABG patients is the superior strategy, this should be offered to all patients in this entity.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Conditions

Moderate Mitral Regurgitation

Intervention

CABG alone, CABG + Mitral repair

Location

Dep. of Cardiothoracic Surgery, Aarhus University Hospital, Skejby,
Aarhus
Denmark
8000

Status

Recruiting

Source

University of Aarhus

Results (where available)

View Results

Links

Clinical Trials [531 Associated Clinical Trials listed on BioPortfolio]

Should we Repair Ischemic Mitral Regurgitation?

The purpose of this study is to assess whether adding mitral valve repair to coronary artery bypass grafting improves outcome in patients with ischemic mitral regurgitation.

Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation

People with coronary artery disease (CAD) or people who have had a heart attack may develop a leak in the mitral valve of their heart and may therefore need to undergo surgery to fix the v...

Repair of Ischemic Mitral Regurgitation: Comparison Between Flexible and Rigid Annuloplasty Rings

Mitral valve repair for ischemic mitral regurgitation is performed primarily by annuloplasty. There is some degree of late failure, which may be due in part to the type of ring employed. W...

Evaluation of Outcomes Following Mitral Valve Repair/Replacement in Severe Chronic Ischemic Mitral Regurgitation

Background: - To evaluate the outcomes of mitral valve repair or replacement in patients with severe mitral valve leakage (regurgitation), researchers at the National Institutes of Health...

Mitral Loop Cerclage(MLC) for Reducing Functional Mitral Regurgitation

To evaluate safety and feasibility of Mitral Loop Cerclage(MLC) Annuloplasty with CSTV for repair of functional mitral regurgitation.

PubMed Articles [5219 Associated PubMed Articles listed on BioPortfolio]

Surgical Treatment of Moderate Ischemic Mitral Regurgitation.

Background Ischemic mitral regurgitation is associated with increased mortality and morbidity. For surgical patients with moderate regurgitation, the benefits of adding mitral-valve repair to coronary...

Surgical Treatment of Moderate Ischemic Mitral Regurgitation.

To the Editor: Smith et al. (Dec. 4 issue)(1) report that adding mitral-valve repair to coronary-artery bypass grafting (CABG) did not result in a clinically meaningful benefit. These results could ju...

Surgical Treatment of Moderate Ischemic Mitral Regurgitation.

To the Editor: Smith et al. (Dec. 4 issue)(1) report that adding mitral-valve repair to coronary-artery bypass grafting (CABG) did not result in a clinically meaningful benefit. These results could ju...

Surgical Treatment of Moderate Ischemic Mitral Regurgitation.

To the Editor: Smith et al. (Dec. 4 issue)(1) report that adding mitral-valve repair to coronary-artery bypass grafting (CABG) did not result in a clinically meaningful benefit. These results could ju...

Surgical Treatment of Moderate Ischemic Mitral Regurgitation.

To the Editor: Smith et al. (Dec. 4 issue)(1) report that adding mitral-valve repair to coronary-artery bypass grafting (CABG) did not result in a clinically meaningful benefit. These results could ju...

Medical and Biotech [MESH] Definitions

Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.

Abnormal protrusion or billowing of one or both of the leaflets of MITRAL VALVE into the LEFT ATRIUM during SYSTOLE. This allows the backflow of blood into left atrium leading to MITRAL VALVE INSUFFICIENCY; SYSTOLIC MURMURS; or CARDIAC ARRHYTHMIA.

A type of heart valve surgery that involves the repair, replacement, or reconstruction of the annulus of the MITRAL VALVE. It includes shortening the circumference of the annulus to improve valve closing capacity and reinforcing the annulus as a step in more complex valve repairs.

Narrowing of the passage through the MITRAL VALVE due to FIBROSIS, and CALCINOSIS in the leaflets and chordal areas. This elevates the left atrial pressure which, in turn, raises pulmonary venous and capillary pressure leading to bouts of DYSPNEA and TACHYCARDIA during physical exertion. RHEUMATIC FEVER is its primary cause.

A condition characterized by a combination of OSTIUM SECUNDUM ATRIAL SEPTAL DEFECT and an acquired MITRAL VALVE STENOSIS.

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