Synthesis of Glutathione From Low Birth Weight Newborn Babies

16:11 EST 27th February 2015 | BioPortfolio

Summary

The aim of the study is to determine mechanisms leading to glutathione deficiency in low birth weight newborn babies. Compared to full term neonates, depletion in this population may be due to a decreased synthesis rate or to an enhanced utilization or a combination of both mechanisms.The protocol is constituted of two steps. The objective of the first step is to quantify the blood concentration of glutathione in the artery and the vein of umbilical cord in full term newborn babies. Objectives of the second step are to determine if the glutathione synthesis rate, measured in vitro, is lower in erythrocytes collected from umbilical cord blood of low weight newborn babies compared to full term newborn babies. In this case, the next objective will be to determine if the adjunction of an excess of cysteine in vitro can restore the glutathione synthesis rate in these cells.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Conditions

Low Birth Weight

Intervention

Blood sample collection

Location

CHU de Nantes
Nantes
France
44000

Status

Recruiting

Source

Nantes University Hospital

Results (where available)

View Results

Links

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Medical and Biotech [MESH] Definitions

An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less.

The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.

An infant whose weight at birth is less than 1000 grams (2.2 lbs), regardless of gestational age.

An infant whose weight at birth is less than 1500 grams (3.3 lbs), regardless of gestational age.

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