Olanzapine in the Treatment of Anorexia Nervosa

2014-08-26 22:33:47 | BioPortfolio

Summary

This study compared 10 weeks of treatment with olanzapine versus placebo in adolescent females with anorexia nervosa-restricting type who were undergoing acute treatment on an inpatient unit or a day hospital program that specializes in the treatment of eating disorders.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Anorexia Nervosa

Intervention

olanzapine, placebo

Location

Schneider Children's Hospital
New Hyde Park
New York
United States
11040

Status

Completed

Source

North Shore Long Island Jewish Health System

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-26T22:33:47-0400

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Olanzapine Versus Placebo for Outpatients With Anorexia Nervosa

Anorexia Nervosa (AN) is a serious illness associated with substantial morbidity and mortality. Weight restoration is a treatment priority, and better treatments are needed.

Olanzapine in the Treatment of Patients With Anorexia Nervosa

The purpose of the study is to evaluate the efficacy of an anti-psychotic medication, Olanzapine, in achieving desired weight gain in patients identified as having Anorexia Nervosa, either...

Energy Homeostasis in Anorexia Nervosa

The purpose of this study is to investigate the potential biological predispositions that contribute to the difficulty patients with anorexia nervosa have in maintaining normal weight.

Effectiveness of Atypical Antipsychotic Medication for Outpatients With Anorexia Nervosa

This study will compare the effectiveness of two atypical antipsychotic medications, olanzapine and aripiprazole, in treating people with anorexia nervosa.

Open Trial of Family-Based Treatment for Anorexia Nervosa

This open trial seeks to investigate the feasibility and effectiveness of delivering a newly manualized family-based treatment for adolescents with anorexia nervosa at a site beyond the tr...

PubMed Articles [1160 Associated PubMed Articles listed on BioPortfolio]

Binge eating as a meaningful experience in bulimia nervosa and anorexia nervosa: a qualitative analysis.

Clinical studies describe binge eating as a reaction to hunger, negative affect, or the need to dissociate. However, little is known about the meanings that women with bulimia nervosa and anorexia ner...

Avoiding Medical Complications During the Refeeding of Patients With Anorexia Nervosa.

Nutritional rehabilitation and weight restoration are key underpinnings of the treatment protocol for patients with anorexia nervosa. While their inherent state of malnutrition and weight loss is cert...

Relevance of Neuroimaging Findings for Diagnoses and Treatment of Adolescent Anorexia nervosa.

Anorexia nervosa is associated with a marked loss of brain volumes during the acute stage of the disease. Due to the advances in neuroimaging methods during the last years our understanding of the con...

Are there Specific Factors in the Psychotherapy of Anorexia nervosa?

The present literature review examines the question of how general and specific factors can be differentiated in the psychotherapy of anorexia nervosa. Over the past 10 years different research trends...

Elevated cognitive control over reward processing in recovered female patients with anorexia nervosa.

Individuals with anorexia nervosa are thought to exert excessive self-control to inhibit primary drives.

Medical and Biotech [MESH] Definitions

The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.

An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)

A disorder associated with three or more of the following: eating until feeling uncomfortably full; eating large amounts of food when not physically hungry; eating much more rapidly than normal; eating alone due to embarrassment; feeling of disgust, DEPRESSION, or guilt after overeating. Criteria includes occurrence on average, at least 2 days a week for 6 months. The binge eating is not associated with the regular use of inappropriate compensatory behavior (i.e. purging, excessive exercise, etc.) and does not co-occur exclusively with BULIMIA NERVOSA or ANOREXIA NERVOSA. (From DSM-IV, 1994)

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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