A Model for Genetic Susceptibility: Melanoma
Summary
The goal of this study is to find out if some people are more likely to get melanoma, a form of skin cancer, than others are. To do this we will compare people who have had more than one melanoma to people who have had only one melanoma and to people who are similar but who have not developed melanoma.
People respond to the environment in different ways. Some may be born with genes that make them more likely to get this type of skin cancer. Each person has many ways to repair normal damage to their genes. Specific genes may affect the repair of sun damage. Other genes affect the way the skin itself reacts to the sun. We want to find out which genes have normal changes in them and lead to different responses to exposures, such as the sun. We also want to find out if sun habits are related to the way these genes work.
Description
The purpose of this study is to better understand genetic susceptibility to melanoma and the interactions of specific polymorphisms with each other and with environmental factors.
To accomplish this, buccal swabs or blood specimens from patients with melanoma (either single primary or multiple primary) have been collected. Specimens will be prepared in the Epidemiology Laboratory at MSKCC. They will be analyzed at MSKCC for INK4A (and functional assays for DNA repair capacity when blood is available) and the melanocortin gene (MC1R), at the University of North Carolina for polymorphisms in DNA repair genes and immune function genes, at the University of Pennsylvania for polymorphisms in the melanocortin receptor gene (MC1R) and immune function genes, and at the University of California (Irvine) for polymorphisms in metabolizing genes (P450's and GST's). Samples will be banked at MSKCC and the University of New Mexico. In order to perform this study, subjects from population-based registries in the United States (New Jersey, North Carolina, Michigan, San Diego/Imperial Counties), Canada (Cancer Care Ontario, British Columbia), Italy (Turin), Australia (New South Wales, Tasmania), were interviewed, asked to provide blood or buccal swab samples and asked to provide permission to obtain and review slides of their primary melanoma. This study is now closed to accrual.
Study Design
Observational Model: Case Control, Time Perspective: Prospective
Conditions
Melanoma
Intervention
Questionnaire, Questionnaire
Location
Memorial Sloan-Kettering Cancer Center
New York
New York
United States
10065
Status
Active, not recruiting
Source
Memorial Sloan-Kettering Cancer Center
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00591500
- Information obtained from ClinicalTrials.gov on February 28, 2013
Medical and Biotech [MESH] Definitions
Cattell Personality Factor Questionnaire
Self report questionnaire which yields 16 scores on personality traits, such as reserved vs. outgoing, humble vs. assertive, etc.
Delphi Technique
An iterative questionnaire designed to measure consensus among individual responses. In the classic Delphi approach, there is no interaction between responder and interviewer.
Manifest Anxiety Scale
True-false questionnaire made up of items believed to indicate anxiety, in which the subject answers verbally the statement that describes him.
Melanoma, Amelanotic
An unpigmented malignant melanoma. It is an anaplastic melanoma consisting of cells derived from melanoblasts but not forming melanin. (Dorland, 27th ed; Stedman, 25th ed)
Cornell Medical Index
Self-administered health questionnaire developed to obtain details of the medical history as an adjunct to the medical interview. It consists of 195 questions divided into eighteen sections; the first twelve deal with somatic complaints and the last six with mood and feeling patterns. The Index is used also as a personality inventory or in epidemiologic studies.
Clinical Trials
Prospective Measurement of Post-Treatment Lymphedema
The goal of this study is to measure the amount of limb swelling (lymphedema) that sometimes occurs after melanoma treatment, and to find out how people feel and react to the diagnosis and...
Questionnaire in Screening Older Patients With Cancer
RATIONALE: A screening questionnaire may help doctors plan better treatment for older patients with cancer. PURPOSE: This clinical trial is studying a questionnaire in screening older pat...
ADHEPTA Study: Adherence Questionnaire in Hepatitis C
Main objective: To study and validate a questionnaire measuring treatment adherence in patients with Hepatitis C virus (HCV) infection. Design of the study: Multicentric, prospective, epi...
Development and Validation of the Food Acceptability Questionnaire
The Food Acceptability Questionnaire (FAQ) is a self-report measure of palatability, ease of preparation, satisfaction, and perceived benefits and adverse effects related to a prescribed o...
French Validation Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ) Questionnaire
Low back pain is a very common disease. Among the persons suffering of acute low back pain, about 10% are at risk of developping chronic pain. A screening questionnaire assessing this risk...
PubMed Articles
Sun behaviour patterns and perception of illness among melanoma patients.
Background Melanoma is one of the most aggressive skin tumours for which the major risk factor is ultraviolet radiation. Sun protection is extremely important, especially for melanoma patients who,...
The objective of this study was to translate and adapt to Spanish the Québec Sleep Questionnaire (QSQ).
The MOOD Questionnaire: Adaptation and validation of the Spanish version.
Background: The aim of this study was to analyze the psychometric properties of the Spanish version of the MOOD Questionnaire in child population. This instrument was developed to cover the existing g...
Questionnaire.
BACKGROUND: Malnutrition in hospitalised patients is often underestimated. The present study aimed to evaluate the validity of a questionnaire for the semi-quantitative evaluation of food intake compa...
