Safety and Efficacy of CelTx for Oral Soft Tissue Regeneration
Summary
The purpose of this study is to evaluate CelTx as a safe and effective alternative to palatal tissue in the treatment of subjects (with recession-type defects) who have an insufficient zone of attached gingiva associated with at least two nonadjacent teeth.
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Gingival Recession
Intervention
CelTx, Autologous palatal tissue
Location
Nevins Perio, LLC
Boston
Massachusetts
United States
02114
Status
Completed
Source
Organogenesis
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00587834
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Gingival Recession
Exposure of the root surface when the edge of the gum (GINGIVA) moves apically away from the crown of the tooth. This is common with advancing age, vigorous tooth brushing, diseases, or tissue loss of the gingiva, the PERIODONTAL LIGAMENT and the supporting bone (ALVEOLAR PROCESS).
Gingival Overgrowth
Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
Fibromatosis, Gingival
Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)
Transplantation, Heterotopic
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Gingival Pocket
An abnormal extension of a gingival sulcus not accompanied by the apical migration of the epithelial attachment.
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PubMed Articles
Gingival recession: part 1. Aetiology and non-surgical management.
Gingival recession is a common finding in many patients. Some patients will not be concerned whereas others will have aesthetic concerns or complain of sensitivity. This paper highlights the aetiology...
Gingival recession: part 2. Surgical management using pedicle grafts.
This paper is the second in a three part series looking at the aetiology and management of gingival recession. Part one discussed the aetiology and non-surgical management and this part aims to discus...
Orthodontic treatment of gingival recession: criteria of treatment.
Gingival recession is a complex phenomenon. Root coverage results can be predictable regarding to the anatomy of the area. This includes the width of keratinized and attached gingiva, the buccolingual...
Gingival recession: part 3. Surgical management using free grafts and guided tissue regeneration.
This paper is the third in a three part series looking at the aetiology and management of gingival recession. Part 1 in this series discussed the aetiology of gingival recession and the non-surgical m...
Alkan EA, Parlar A. EMD or subepithelial connective tissue graft for the treatment of single gingival recessions: a pilot study. J Periodont Res 2011; doi: 10.1111/j.1600-0765.2011.01381.x. © 2011 Jo...
