Feasibility Study of Cone Beam Imaging for Radiation Therapy Treatment Verification
Summary
The purpose of this study is to test a new technology for obtaining x-ray images of your treatment fields when you are positioned on the treatment machine, to determine whether this new system is as reliable and easy to use as conventional systems.. These so-called portal images are normally taken on a weekly basis, prior to your radiation treatment. The new portal imaging system to be tested is designed to produce better quality images than are currently achievable, but with no additional dose or added treatment time.
Description
The objective of this proposal is to test the clinical practicality of a new technology; cone beam imaging, for verification of treatment set up accuracy of cancer patients receiving radiation therapy. Currently, treatment accuracy is checked via use of 2-dimensional projection x-rays taken with the megavoltage treatment beam and electronic portal imaging devices (EPID). Typically 2 orthogonal portal images are obtained to confirm patient positioning accuracy. This method of treatment verification, however, usually provides images of poor quality and lacks true 3D information, thus making it difficult for the radiation oncologist to definitively confirm treatment accuracy. New generation EPIDs are capable of obtaining higher quality images at significantly lower imaging doses. Thus, for the same total imaging dose new generation EPIDs permit acquisition of many projection images rather than just 2 or 3. The combination of more images and higher quality images should permit more definitive assessment of treatment accuracy. We propose here to test the clinical practicality and reliability of a new prototype portal imaging system.
Study Design
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Conditions
Radiation Treatment for Tumors
Intervention
Cone Beam Imaging
Location
Memorial Sloan Kettering Cancer Center
New York
New York
United States
10065
Status
Active, not recruiting
Source
Memorial Sloan-Kettering Cancer Center
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00582959
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Respiratory-gated Imaging Techniques
Timing the acquisition of imaging data to specific points in the breathing cycle to minimize image blurring and other motion artifacts. The images are used diagnostically and also interventionally to coordinate radiation treatment beam on/off cycles to protect healthy tissues when they move into the beam field during different times in the breathing cycle.
Cone-beam Computed Tomography
Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
Spiral Cone-beam Computed Tomography
Modality of computed tomography in which the patient is irradiated in a spiral path around the body with a cone or pyramid-shaped beam.
Lasers
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
Cone Opsins
Photosensitive proteins expressed in the CONE PHOTORECEPTOR CELLS. They are the protein components of cone photopigments. Cone opsins are classified by their peak absorption wavelengths.
Clinical Trials
The purpose of this study is to test a new and possibly more accurate method of positioning patients with liver tumors in preparation for radiation treatment. The positioning of patients...
To evaluate the use of cone beam computed tomography in treating head and neck to hopefully reduce side effects
The purpose of this study is to use cone-beam CT scans to more accurately position the tumor during radiation and to see whether this method is more effective than the standard method of u...
Cone Beam CT Scanning in Lung and Bladder Cancer.
To study changes in tumor and normal organ size and/or position which occur during a course of radiation treatments.
Cone Beam Computed Tomography (CT) Bladder
This study is designed to investigate whether daily images of the pelvis and bladder using a device called a cone beam CT scanner will help to increase the accuracy of radiotherapy treatme...
PubMed Articles
Image-guided radiation therapy for muscle-invasive bladder cancer.
Organ preservation protocols that incorporate chemoradiotherapy have shown good efficacy in bladder cancer. Owing to changes in rectal filling, urinary inflow and subsequent bladder volume with bladde...
Increasingly stringent guidelines for the use of cone-beam computed tomography (CBCT).
Beam characteristics and radiation output of a kilovoltage cone-beam CT.
This study presents beam characteristics of five recently available x-ray beams produced by an on-board imager (OBI 1.4) for acquiring kilovoltage cone-beam computed tomography (kV-CBCT) and investiga...
Image-guided radiation therapy : Paradigm change in radiation therapy.
CLINICAL ISSUE: The introduction of image-guided radiotherapy (IGRT) has changed the workflow in radiation oncology more dramatically than any other innovation in the last decade...
Comparative study of a low-Z cone-beam computed tomography system.
Computed tomography images have been acquired using an experimental (low atomic number (Z) insert) megavoltage cone-beam imaging system. These images have been compared with standard megavoltage and k...
