Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
Summary
New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others.
In this prospective, open-label, randomized trial, we enroll patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day rifampin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital, or one of its two community-based affiliated hospitals which are all located in southwestern Korea between 2006 and 2009.
Study Design
Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Scrub Typhus
Intervention
doxycycline, rifampin
Location
Chosun University Hospital
Gwang-Joo
Jeollanamdo
Korea, Republic of
501-717
Status
Recruiting
Source
Chosun University Hospital
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00568711
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Trombiculiasis
Infestation with mites of the genus Trombicula, whose larvae carry the rickettsial agent of scrub typhus.
Orientia Tsutsugamushi
A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.
Scrub Typhus
An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash.
Rickettsia Typhi
The etiologic agent of murine typhus (see TYPHUS, ENDEMIC FLEA-BORNE).
Typhus, Endemic Flea-borne
An infectious disease clinically similar to epidemic louse-borne typhus (TYPHUS, EPIDEMIC LOUSE-BORNE), but caused by RICKETTSIA TYPHI, which is transmitted from rat to man by the rat flea, Xenopsylla cheopis.
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PubMed Articles
Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi.
We report on a scrub typhus patient who contracted meningoencephalitis during doxycycline administration. This is the first case of scrub typhus in which doxycycline concentrations were measured in se...
BACKGROUND: For both dengue and scrub typhus, acute respiratory failure (ARF) is a serious complication. The present study was carried out in order to investigate the clinical co...
Scrub typhus associated macrophage activation syndrome.
Macrophage activation syndrome (MAS) is a rare phenomenon that occurs either primarily or secondary to a multitude of conditions, including juvenile rheumatoid arthritis most commonly, and other infec...
Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus.
ABSTRACT: BACKGROUND: This study was designed to investigate the clinical significance of hypoalbuminemia as a marker of severity and mortality in patients with Scrub typhus. METHODS: The patients wit...
Scrub typhus-induced serious gastric ulcer bleeding.
A 67-year-old woman presented with melena and general weakness. Upper gastrointestinal (GI) endoscopy revealed multiple ulcers and projectile bleeding in the stomach. She also complained of a 10-day h...
