Treatment of Patients With Blepharitis and Facial Rosacea
Summary
To determine the safety and efficacy of sub-antimicrobial dose doxycycline in the treatment of patients who have both blepharitis and facial rosacea
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Conditions
Blepharitis
Intervention
doxycycline, placebo
Location
Pleasant Valley Ophthalmology
Little Rock
Arkansas
United States
72212
Status
Completed
Source
Galderma
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00560703
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Blepharitis
Inflammation of the eyelids.
Therapeutic Misconception
Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.
Doxycycline
A synthetic TETRACYCLINE derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (MALARIA, FALCIPARUM).
Placebo Effect
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Clinical Trials
Topical IL-1-Ra for Treatment of Posterior Blepharitis
The purpose of this study is to determine the effectiveness and safety of Topical Interleukin-1-Receptor Antagonist in treatment of signs and symptoms of posterior blepharitis
The purpose of this research project is to determine the effects of oral tetracycline such as Minocycline (Minocin) on tear film composition and tear lipid (meibomian gland secretions) cha...
Tea Tree Oil in the Treatment of Chronic Blepharitis
The purpose of this study is to determine: - The prevalence of Demodex sp. in chronic blepharitis. - The efficacy of the treatment of topical Tree Tea Oil in chronic blepharitis fo...
Safety and Efficacy Study of AzaSite® in Subjects With Blepharitis
The purpose of this study is to evaluate the safety and efficacy of AzaSite® ophthalmic solution, 1% on signs & symptoms of blepharitis and tear cytokine and eyelid bacterial load levels
Safety and Efficacy Pilot Study of AzaSite® for Four Weeks in Subjects With Blepharitis
The purpose of this study is to evaluate the safety and efficacy of AzaSite® ophthalmic solution, 1% on signs and symptoms of blepharitis.
PubMed Articles
Successful treatment of blepharitis with bibrocathol (Posiformin(®) 2 %).
BACKGROUND: Bibrocathol is a well-established antiseptic drug for the treatment of acute eyelid diseases like blepharitis. Despite its frequent use in clinical practice, no controlled clinical trial o...
Pathogenic role of Demodex mites in blepharitis.
PURPOSE OF REVIEW: To summarize the key literature and our research experience regarding Demodex infestation as a potential cause of ocular inflammatory diseases with a special emphasis on Demodex ble...
OBJECTIVES: Preliminary evidence suggested that doxycycline and rifampin might stop or slow the progression of Alzheimer's disease (AD). We carried out a randomized trial to confirm or refute these fi...
Treatment of ocular rosacea with 40 mg doxycycline in a slow release form.
Background: About 30-50 % of rosacea patients have ocular involvement. The symptoms range from a foreign-body sensation to conjunctivitis or blepharitis and may even include severe corneal ulcerations...
Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi.
We report on a scrub typhus patient who contracted meningoencephalitis during doxycycline administration. This is the first case of scrub typhus in which doxycycline concentrations were measured in se...
