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Open-Label Trial of the Use of Minocycline in the Treatment of Asthma

Summary

The tetracycline minocycline has, in addition to its anti-infective properties,
anti-inflammatory properties which may be of use in the treatment of asthma. This study
evaluates the benefit of minocycline as add-on therapy for adults with asthma.

Description

Adult asthmatic (ages 18 to 75 years) with a history of moderate to severe persistent asthma
are given minocycline capsules as add-on therapy for treatment of asthma. Treatment is for
one year. Dosing begins at 150 mg twice daily and can increase every eight weeks by 50mg BID
to a maximum of 250 mg twice daily. This is as per patient tolerance as minocycline can
cause dizziness and stomach upset, as well as effects of liver enzymes.Patients undergo
routine blood toxicity screens every two months, at which time spirometry is performed
Exclusion criteria: pregnant women (adequate contraception in mandated) previous history of
hypersensitivity to tetracyclines, chronic liver disease Outcome measures: improvement in
FEV1 and other spirometric parameters, decrease in oral steroid requirements, change in
total serum IgE, improvement in quality of life

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Asthma

Intervention

minocycline

Location

SUNY Downstate Medical Center
Brooklyn
New York
United States
11203

Status

Active, not recruiting

Source

State University of New York - Downstate Medical Center

Results (where available)

View Results

MESH Definitions

Minocycline

A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.

Asthma, Exercise-induced

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

Anti-asthmatic Agents

Drugs that are used to treat asthma.

Orciprenaline

A beta-adrenergic agonist used in the treatment of asthma and bronchospasms.

Tretoquinol

An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.

Clinical Trials 807 Associated Clinical Trials

Safety and Efficacy Study of Copaxone Administered in Combination With Minocycline
This study investigates the add-on effect of oral minocycline in subjects treated with daily injection of Copaxone. Copaxone and minocycline are thought to have differential modes of actio...
Pilot Study of Minocycline in Huntington's Disease
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Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults
The purpose of this study is to determine the effectiveness of minocycline, an antibiotic, in lessening the decreased mental function sometimes caused by anti-HIV drugs.
Role of Minocycline in First Episode Psychosis
The purpose of this study is to determine whether the addition of minocycline or placebo to treatment as usual (TAU): 1. prevents the accumulation of negative symptoms and intellectual...
Study to Compare the Acne Relapse Rate of Oral Minocycline to Oral Minocycline in Combination With Topical Tretinoin, Followed by Topical Tretinoin Alone
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PubMed Articles 1688 Associated PubMed Articles

A case of anaphylaxis to oral minocycline.
Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. To date, there has been only one case report of anaphylaxis to minocycline. We report here...
Effects of minocycline on Na(+) currents in rat dorsal root ganglion neurons.
Minocycline is an inhibitor of microglial activation and proliferation. Minocycline suppresses pain-related behaviors in many different pain states, which correlates closely with its inhibition of mic...
Cytoprotective activity of minocycline includes improvement of mitochondrial coupling: the importance of minocycline concentration and the presence of VDAC.
Available data indicate that minocycline, an antibiotic of the tetracycline family, has cytoprotective properties due to a direct interaction with mitochondria. Yet, the data in the case of isolated m...
Pharmacokinetics and tissue distribution of minocycline hydrochloride in horses.
Objective-To determine the pharmacokinetics and tissue distribution of minocycline in horses. Animals-5 healthy Thoroughbred mares for the pharmacokinetic experiment and 6 healthy Thoroughbred mares f...
Prospects for Minocycline Neuroprotection.
Minocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have t...

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