Study of NPL-2003 in Adolescents With Obsessive Compulsive Disorder (OCD)
Summary
The purpose of this study is to investigate the effect of NPL-2003 on the symptoms of Obsessive Compulsive Disorder (OCD) in an adolescent population.
Study Design
Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Conditions
Obsessive Compulsive Disorder
Intervention
NPL-2003
Location
New York State Psychiatric Institute, Columbia University
New York
New York
United States
10032
Status
Terminated
Source
Neuropharm
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00515255
- Information obtained from ClinicalTrials.gov on July 15, 2010
Medical and Biotech [MESH] Definitions
Obsessive-compulsive Disorder
An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
Compulsive Personality Disorder
Disorder characterized by an emotionally constricted manner that is unduly conventional, serious, formal, and stingy, by preoccupation with trivial details, rules, order, organization, schedules, and lists, by stubborn insistence on having things one's own way without regard for the effects on others, by poor interpersonal relationships, and by indecisiveness due to fear of making mistakes.
Continuous Positive Airway Pressure
A technique of respiratory therapy, in either spontaneously breathing or mechanically ventilated patients, in which airway pressure is maintained above atmospheric pressure throughout the respiratory cycle by pressurization of the ventilatory circuit. (On-Line Medical Dictionary [Internet]. Newcastle upon Tyne(UK): The University Dept. of Medical Oncology: The CancerWEB Project; c1997-2003 [cited 2003 Apr 17]. Available from: http://cancerweb.ncl.ac.uk/omd/)
Serotonin Uptake Inhibitors
Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. These agents have been used in treatment of depression, panic disorder, obsessive-compulsive behavior, and alcoholism, as analgesics, and to treat obesity and bulimia. Many of the ADRENERGIC UPTAKE INHIBITORS also inhibit serotonin uptake; they are not included here.
Agoraphobia
Obsessive, persistent, intense fear of open places.
Clinical Trials
Family Based Treatment of Early Childhood Obsessive Compulsive Disorder
This study will evaluate a treatment program for young children with Obsessive Compulsive Disorder (OCD) and their families.
Pilot Study of NPL-2003 in Adults With Obsessive-Compulsive Disorder (OCD)
Obsessive-compulsive disorder (OCD) is a common psychiatric illness that affects up to 2-3% of the population. People with OCD experience anxiety-provoking, intrusive thoughts, known as ob...
Adjunctive Glycine for Obsessive Compulsive Disorder
The purpose of this study is to determine whether individuals with obsessive compulsive disorder who will take a preparation of the amino acid glycine in addition to their current treatmen...
Topiramate Augmentation in the Treatment of Obsessive-Compulsive Disorder
A 12-week program to examine the effectiveness of topiramate in adjunctive treatment for adults with obsessive-compulsive disorder and who are currently on serotonin reuptake inhibitor med...
Escitalopram for the Treatment of Obsessive Compulsive Disorder (OCD)
The purpose of this study is to assess the efficacy of Escitalopram in the treatment of obsessive compulsive disorder and to determine the optimal treatment dose.
PubMed Articles
The psychometric properties of the Obsessive Compulsive Inventory-Child Version (OCI-CV) were examined in ninety-six youth with a primary/co-primary diagnosis of obsessive-compulsive disorder (OCD). A...
Background: There has been debate about whether obsessive-compulsive disorder (OCD) should be classified as one of the anxiety disorders, or should rather be categorized with obsessive-compulsive spec...
Background: Inflated responsibility is the main feature of cognitive-behavioural models of obsessive-compulsive disorder (OCD). However, few studies have examined the effect of cognitive-behavioural g...
ABSTRACT Obsessive-compulsive disorder (OCD) is a disabling neuropsychiatric disorder, which rarely spontaneously remits. We present a case of a patient suffering with severe OCD whose symptoms disapp...
Acne is one of the most common dermatological diseases, and obsessive compulsive disorder is among the most frequent psychiatric conditions seen in dermatology clinics. Comorbidity of these conditions...
