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Infliximab and Methotrexate in Ankylosing Spondylitis

2014-08-27 03:37:07 | BioPortfolio

Summary

There is a great individual variability of pharmacokinetic of infliximab in patients treated for ankylosing spondylitis (AS). Moreover, some patients have a treatment with methotrexate (MTX), others have not.

Thus, the aim of this study is to assess the effect of MTX on the pharmacokinetic properties of infliximab in 30 patients treated for AS, 15 with MTX, 15 without.

Study Design

Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label

Conditions

Ankylosing Spondylitis

Intervention

infliximab

Location

University Hospital Jean MINJOZ -Besançon
Besancon
France
25030

Status

Completed

Source

University Hospital, Tours

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:37:07-0400

Clinical Trials [239 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Low Dose Infliximab in Ankylosing Spondylitis (Study P04352)(COMPLETED)

This is a randomized, double-blind, multi-center, placebo-controlled study with two parallel treatment groups (placebo and infliximab) in subjects with ankylosing spondylitis (AS) to evalu...

A Study of Infliximab (Remicade) in Patients With Ankylosing Spondylitis.

A study of the safety and efficacy of Infliximab (Remicade) versus placebo in subjects with Ankylosing Spondylitis

A Study of Infliximab (Remicade) in Patients With Ankylosing Spondylitis.

A study of the safety and efficacy of Infliximab (Remicade) versus placebo in subjects with Ankylosing Spondylitis

Effectiveness and Safety of Early Treatment With Infliximab for Hip Arthritis Associated With Ankylosing Spondylitis (P06451)

This trial is designed to measure improvement of hip involvement in patients with ankylosing spondylitis after receiving 4 doses of infliximab. Patients will receive infliximab 5 mg/kg (a...

An Observational Study of Infliximab in Participants Suffering From Ankylosing Spondylitis With Hip Involvement

The purpose of this observational (a study that follows participants forward in time) study is to compare the functional improvement of hip joint using Harris hip score between 2 treatment...

PubMed Articles [159 Associated PubMed Articles listed on BioPortfolio]

A multicenter, open-label, long-term study of three-year infliximab administration in Japanese patients with ankylosing spondylitis.

To investigate the efficacy, safety, and pharmacokinetics of infliximab (IFX) in Japanese patients with active ankylosing spondylitis (AS).

Serum RDW and MPV in ankylosing spondylitis: Can they show the disease activity?

To determine RDW and MPV levels in Ankylosing Spondylitis (AS) and to investigate their relations with disease activity.

Cervical Spine Fracture and Other Diagnoses Associated with Mortality in Hospitalized Ankylosing Spondylitis Patients.

Little data exist regarding mortality in Ankylosing Spondylitis (AS). We assessed diagnoses associated with in-hospital mortality in AS using a population-based inpatient dataset.

Diagnostic Prevalence of Ankylosing Spondylitis Using Computerized Health Care Data, 1996 to 2009: Underrecognition in a US Health Care Setting.

Few studies have assessed the prevalence and features of axial spondyloarthritis (axSpA) and ankylosing spondylitis in diverse, population-based, community settings.

Single anterior approach for cervical spine fractures at C5-T1 complicating ankylosing spondylitis.

To evaluate the outcomes of anterior approach for cervical spine fractures at C5-T1 in patients with ankylosing spondylitis (AS) and study the problems encountered in diagnosis and treatment.

Medical and Biotech [MESH] Definitions

A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.

A nonsteroidal anti-inflammatory agent with potent analgesic and antiarthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ankylosing SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).

Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. It is strongly associated with acute anterior uveitis (UVEITIS, ANTERIOR); ANKYLOSING SPONDYLITIS; and REACTIVE ARTHRITIS.

A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.

Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.

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