Clinical Trials Database

01:19 EDT 10th October 2015 | BioPortfolio

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For example view clinical trials on Prostate Cancer.

Showing Clinical Trials 1–25 of 83,000+

Friday 9th October 2015

Evaluate the Efficacy, Safety and Tolerability of a Non-hormonal Intravaginal Gel in Postmenopausal Women With Symptoms of Vaginal Dryness.

Primary: Evaluation of improved vaginal moisture in postmenopausal women. Secondary: the improvement of symptoms resulting from the dryness Rating (VHI), evaluation of the decrease in vaginal pH, assessment of Sexual Function Index female (FSFI), evaluation of adherence to study treatment by patient diary, assessing the acceptability of the product and subjective assessment of the patient as the itching and stinging / burning, beyond the safety assessment.

A Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of Oral PTH (1-34) Formulations in Healthy Subjects

This study will have one stage consisting of multiple treatment visits. The study is designed to assess the safety and bioavailability of Entera's oral PTH(1 - 34) in adult male healthy volunteers in various formulation. The study is also designed to assess the reproducibility of pharmacokinetic profiles with various formulations.

Low Doses of Ketamine and Postoperative Quality of Recovery

There are evidences that intraoperative administration of low doses of ketamine may contribute to control the postoperative pain by acting on the NMDA channel, reducing the effects related to the tolerance and hyperalgesia induced by opioids. This study aims to evaluate the effects of administration of this agent not only as an analgesic but also its role in the quality of recovery from anesthesia, which includes observation of emotional, psychological and physical aspects. Pat...

HSV529 Vaccine in HSV-2 Seropositive Adults

The purpose of the study is to determine the safety of HSV529 vaccine in healthy volunteers with HSV infection and to determine if administration of the HSV529 vaccine increases the immune response in genital skin.

Intranasal Fentanyl in Treatment of Labour Pain

Physiological changes during pregnancy are known to affect the pharmacokinetics of many drugs. Intranasal fentanyl is an interesting option for obstetric analgesia, but its use in pregnant patients has not been established. The investigators studied pharmacokinetics of intranasal fentanyl in labouring women and to subsequently evaluate the maternal and fetal safety after administration.

A Study to Investigate How the Study Drug SHP626 is Eliminated From the Body After One Dose

The purpose of this study is to determine how SHP626 is absorbed and excreted from the body in healthy males.

Testosterone Therapy for Pubertal Delay in Duchenne Muscular Dystrophy

"Observational study of clinical outcomes for testosterone treatment of pubertal delay in Duchenne Muscular Dystrophy" is a single centre observational study that aims to follow the progress of 20 adolescents with Duchenne Muscular Dystrophy (DMD) and delayed puberty who are treated by the Newcastle muscle team, as they are treated with testosterone to induce puberty. The participants will all be treated with the standard stepwise regimen of testosterone injections every 4 week...

AF Substrate Mapping and Guided Ablation

In this study, the investigators aim to identify and characterize, by means of an EnSite Velocity Research Software, the electrophysiological characteristics of substrates that sustain AF in patients with persistent AF and to test whether ablation of such patient-specific substrates might improve the acute and long-term success of conventional catheter ablation therapy.

High Flow Ventilation With Volume Guarantee

The trial is a pilot study performed in the NICU's at Oslo University Hospital and Haukeland University Hospital preparing a multi-center randomized, controlled unblinded cross-over study, comparing high frequency ventilation (HFV) with and without volume guarantee (VG).

Text Messaging for Supporting Quit Attempts

The study is a preliminary research aimed to compare the effectiveness of motivational interview (MI), Personalized text messages (TM) and usual care for outpatients, with focus on smoking cessation as the main outcome. Smokers patients receive brief interventions and nicotine replacement therapy during the hospitalization. After hospitalization discharge smokers will be allocated in a intervention or control arm. In the first and third months, after randomization, the patients...

Efficacy and Safety of Gemcabene in Hypercholesterolemic Patients on Stable Statin Therapy

The purpose of this study is to evaluate the effect of gemcabene on LDL-C and other lipid parameters in hypercholesterolemic patients on a stable dose of a statin.

12-Week-Combined Physical Training In Heart Failure Patients

Purpose: Physical exercise exerts favorable impact on functional capacity (FC) and quality of life (QL) in patients with heart failure (HF). It is believed that the combined aerobic and resistance physical training (CPT) supervised by physical educator is better than only prescription of unsupervised exercise. The aim of this study is to compare the effects of a CPT program on the FC and QL of HF patients with reduced ejection fraction (HFREF) with the practice medical routine ...

Peri-articular Injection Utilizing a Pain Cocktail With and Without Exparel

A prospective, randomized control study will be conducted to compare postoperative pain control in a series of patients treated with either: 1. a local cocktail. 2. a local cocktail plus Exparel. 3. marcaine plus Exparel prior to wound closure following knee arthroplasty.

The Value of Oral Micronized Progesterone in the Prevention of Spontaneous Preterm Birth

This is a randomized, double-blind, placebo-controlled study.

Asthmatuner a Self-management App for Asthma: A Randomized Controlled Multicentre Trial

Primary aim: Evaluating the effect of Asthmatuner on patients´ self-reported asthma control test (ACT/C-ACT) and health-related quality of life (HR-QoL) compared with conventional asthma management. Secondary aim: Evaluating patients´ medical adherence by using Asthmatuner compared with conventional management. Total sample size: Approximately 43 females and males with diagnosed asthma at the age of 6 years or more will be evaluated. Study design: This is a mul...

Whole Body Vibration Training on Body Composition

The purpose of the study is to determine the effect of whole-body vibration (WBV) on body composition, physical fitness, and quality of life.

Impacts of Different Training Modes (Intense Versus Ordinary) on the Immune System and Memory Functions in pwMS

Multiple Sclerosis (MS) is a chronic immune-mediated disease of the central nervous system, accompanied by varying inflammatory manifestations, demyelinization and axonal loss. With chronic progressive or relapsing-remitting disease onsets persons with MS (pwMS) progressively develop impaired functional capacity and show reduced physical activity and cognitive decline compared to healthy controls. The primary aims of rehabilitation in pwMS are therefore to increase levels of ac...

Optimum Micro-osteoperforations Accelerated Tooth Movement Interval

This study is intended to investigate the optimum interval between micro-osteoperforations to accelerate orthodontic tooth movement. Overall, the investigator will be comparing the rate of tooth movement between micro-osteoperforated site and non micro-osteoperforated site. Next, the investigator will be comparing the rate of orthodontic tooth movement for micro-osteperforation performed at 4, 8 and 12 weeks' intervals. In addition, the investigator will be evaluating the pain ...

PAracetamol and NSAID in Combination: A Randomised, Blinded, Parallel, 4-group Clinical Trial

Trial name: PAracetamol and NSAID in combination: A randomised, blinded, parallel, 4-group clinical trial Trial acronym: PANSAID Background: Effective postoperative pain management is essential for the well-being and rehabilitation of the surgical patient. No "gold standard" exists after total hip arthroplasty (THA) and combinations of different non-opioid medications are used with virtually no evidence for additional analgesic efficacy compared to monotherapy. O...

Symbiotics to Prevent Postoperative Infection in Colorectal Cancer

This is a double blind randomized trial in which patients with colorectal cancer undergoing surgery will be selected to receive either a symbiotic formulation or placebo. The researchers will compare incidence of surgical site infection between the study groups.

MindOb: A 12-month Computerized Mindfulness-based Intervention for Obese Individuals

The purpose of this study is to evaluate the efficacy of a daily 12-month computerized mindfulness-based intervention in obese patients diagnosed with Binge Eating Disorder (BED) on: impulsive eating, motivation toward exercise, and weight loss.

Can we Predict Patients at Risk of Long-term Opioid Use After Surgery?

The purpose of this study is to determine the prevalence of delayed opioid cessation after surgery, where delayed opioid cessation is defined as patients taking opioids ≥90 days post-surgery. The study is also looking to determine specific patient factors that independently predict patients at risk of delayed opioid cessation. The study hypothesis is that 5-10% of patients will remain on opioid medications ≥90 days after surgery, and that pre-operative prescription opioid ...

Evaluation of the Animated Cartoon-aided Teaching of Intranasal Corticosteroid Allergic Rhinitis

Correct methods and compliance of intranasal corticosteroid (INCS) is very important for the treatment of allergic rhinitis (AR). The animated cartoon-aided teaching of INCS administration was created to decrease workload of health care professionals. The aim of this study is to compare the achievement of the children with AR in using INCS between the group which were instructed by animated cartoon-aided teaching or oral presentation without demonstration.

Renal Function During Pediatric Anesthesia

It is known that volatile anesthesia, such as sevoflurane, retain water and that this appears more pronounced in children. However, the mechanisms for this effect is unknown and it is not clear if the commonly used anesthetic propofol does the same. In this study the investigators want to compare the fluid and electrolyte conserving effects of sevoflurane and propofol in a pediatric setting and also investigate humoral changes induced by these anesthetics.

Comparative Study of Two Different Techniques to Perform TAP-blocks

The TAP is a space between the muscle layers of the abdominal wall that houses nerves supplying the abdominal skin. Injecting the local anesthetic ropivacaine into this space will block these nerves and prevent pain following c-section. The investigators will compare two different approaches to injecting the local anesthetic in this space. Conventionally, the block is done after surgery is completed and the abdomen is closed. The anesthesiologist introduces a needle through the...