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Clinical Trials Database

11:25 EDT 22nd September 2017 | BioPortfolio

BioPortfolio incorporates data supplied by ClinicalTrials.gov to provide our users with a user-friendly interface to relate clinical trials to associated content on BioPortfolio – news, PubMed papers, corporate profiles and channels.

ClinicalTrials.gov offers up-to-date information for locating clinical trials for a wide range of diseases and conditions.   

For example view clinical trials on Prostate Cancer.

Showing Clinical Trials 1–25 of 120,000+

Friday 22nd September 2017

NRC:Improving Healthcare for Cognitively Impaired Elders and Their Caregivers

An multi-stage mixed-method design will be employed to obtain both qualitative and quantitative data to address two study aims: (1) Evaluate and refine the delivery Reducing Disabilities in Alzheimer's Disease (RD- AD) training to advanced practice nurses and (2) Evaluate and refine the implementation of RD-AD by advanced practice nurses in their medical settings.

Treatment of a PDA With Acetaminophen in Preterm Neonates: Exploring Various Indications

This study will evaluate the use of acetaminophen in preterm infants when a patent ductus arteriosus (PDA) is of concern. We will perform two simultaneous prospective observational studies over a 3 year period. The first will be of infants with clinically significant PDAs beyond 14 days of life who are medically treated with acetaminophen as a means to avoid surgical ligation, and the second will be of infants who received acetaminophen for a PDA closure during the first 2 week...

The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis

The aim of the work is to determine whether the use of immunomodulatory drugs could improve the reproductive of outcome of infertile patients who have autoimmune thyroiditis with positive autoimmune antibodies undergoing IVF-ET.

Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis

This study is intended to compare whether bone marrow aspirate concentrate or platelet rich plasma injections is more effective in treating knee osteoarthritis.

Antiarrhythmic and Cardioprotective Effects of Atorvastatin Versus Magnesium Sulfate in Cardiac Valve Replacement Surgery

This study aims to compare the antiarrhythmic and cardioprotective effects of Atorvastatin versus Magnesium Sulfate after Cardiac valve Replacement Surgery

Supine Position for Colonoscopy Insertion

The purpose of this study is to determine whether the supine position is better than the left lateral horizontal body position to decrease cecal intubation time, patients' pain and the difficulty of colonoscopy insertion.

CD19 /22 CAR T Cells (AUTO3) for the Treatment of B Cell ALL

The purpose of this study is to test the safety and efficacy of AUTO3, a CAR T cell treatment targeting CD19 and CD22 in paediatric or young adult patients with relapsed or refractory B cell acute lymphoblastic leukaemia.

Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases

The postmenopausal women with vaginal bleeding were selected in this cross-sectional study. The basic characteristics information and endometrial blood flow energy index of endometrium were detected by color power Doppler ultrasound, and the energy histogram of endometrium was obtained. The specimen of uterine cytology and endometrial tissue were obtained through minimally invasive endometrium sampler, which were diagnosed by pathology. The statistical data were used to detect ...

Treatment of HFpEF With Nitrate Supplement

The objective of this project is to determine if Neo40, a nitric oxide generating lozenge, when consumed twice daily by subjects with HFpEF, will increase exercise tolerance, decrease symptoms and improve quality of life for patients.

Evaluation of 2 Diets With Different Starch Digestibility Profiles on Daily Glycemic Profile, in T2D Patients

The study is a randomized pilot study. The research hypothesis is that the diet high in SDS content (H-SDS) will lower the daylong glycemic response and improve the glycemic control in patients with type 2 diabetes (T2D) compared to the diet low in SDS content (L-SDS).

Longvida Curcumin Human Pharmacokinetics Study

The primary objective of the study is to characterize the curcumin metabolites of 2 different capsule formulations of curcumin relative to unformulated Curcuma longa extract of Rhizomes including assessing relative bioavailability and absorption/kinetic profile of curcumonoids and their metabolites in human plasma and urine after acute consumption.

Clopidogrel Prevention of Early Arteriovenous (AV) Fistula Thrombosis

The objective of the study is to determine whether clopidogrel reduces the early failure rate of native AV fistulae. This study was originally registered as NCT00067119 which included two protocols, this one and the GRAFT study)

A Study Of Avelumab In Combination With Axitinib In Advanced HCC

To evaluate the safety, efficacy and PK of avelumab in combination with axitinib as first line treatment in patients with advanced HCC

The Active Mind Study

The purpose of this study is to explore whether physical exercise, mindfulness training, or both interventions together can improve cognitive function in individuals with multiple risk factors for the development of dementia in the future.

Effects of Testosterone and Fat Utilization

Evidence is accumulating that there are sex differences in energy and substrate metabolism. The positive or negative consequences of such metabolic differences between men and women need to be evaluated with respect to health outcomes. The importance of aberrant lipid metabolism in metabolic diseases such as obesity, diabetes and cardiovascular disease, makes understanding the distinction between "normal" vs aberrant critical to future treatment and prevention strategies. Sex d...

Microgrid II - Electrocorticography Signals for Human Hand Prosthetics

Neurologic disease with loss of motor function is a major health burden. Brain-computer interfaces (BCI) are systems that use brain signals to power an external device, such as a communication board or a prosthetic device, which may help people with loss of motor function. Electrocorticography (ECoG) has been used to decode hand movements and as a control signal for brain-computer interface (BCI). This study hopes to use a smaller spacing of ECoG to see if a better motor signal...

A National Registry For Patients With Hidradenitis Suppurativa

The goal of this study is to get a better understanding of the skin condition, Hidradenitis Suppurativa, and to find out how the disease affects quality of life. We hope this information will help us improve our treatment for this skin condition

Effect of Involving Community Dwelling Older People Receiving Meals-on-wheels in Activities in Relation to Meals

The clinical study's hypothesis is that community dwelling older people receiving meals-on-wheels can have an improvement in health-related quality of life and muscle strength, being involved in their own food and meals compared to not being involved in their own food and meals; that is usual community home-care and meals-on-wheels.

Preeclampsia Ratio (sFlt-1/PlGF)

The aim of the PRECOG study is to determine in a prospective interventional randomized study whether the implementation of a predictive test based on the sFLT-1/PlGF ratio improves perinatal care and reduces costs, in patients with suspected preeclampsia before 35 weeks of gestation.

SHARE for Persons With Chronic Conditions and Their Family Caregivers

SHARE-CC is an intervention for families facing the challenges of chronic conditions. SHARE-CC (Support, Help, Activities, Resources, and Education) addresses the need for both members of a care dyad to be actively involved in current and future care planning. This intervention aims to increase knowledge of services, improve communication skills and well-being, and facilitate the understanding of care values and preferences in order to create a mutually agreed upon care plan. T...

Supplementation With Vitamin D to Patients With Heart Failure (D-Heart).

In 200 patients with documented systolic heart failure give supplementation with vitamin D in those with a 25-OH- vitamin D < 50nmol/L - or placebo. In those with a vitamin D level

Extended Release Tacrolimus vs. Twice-Daily Tacrolimus

The overall aim of the study is to prospectively investigate the impact of two maintenance calcineurin inhibitor immunosuppressive regimens: once-daily extended release tacrolimus and twice-daily tacrolimus on subpopulations of T and B cells and alloreactive T cells as well as on renal allograft function.

Effectiveness Study of New Generation Bednets in the Context of Conventional Insecticide Resistance in the Democratic Republic of the Congo

Despite the mass distribution of LLINs (long-lasting insecticidal nets) as a Malaria control strategy, populations are still continuously exposed to a high frequency of malarial inoculation in some countries. The situation can be explained by a swift increase in the resistance of Anopheles to common insecticides. To preserve the gains of insecticides and improve their effectiveness, a new generation of bednets treated with piperonyl butoxide combination insectides have emerged....

Storytelling Narrative Communication Intervention for Smoking Cessation in Women Living With HIV

HIV has transformed into a chronic illness due to the advent of effective treatments in the absence of a cure. As a result, the prevalence of non-AIDS defining cancers (NADCs), including lung cancer, has increased three-fold among people living with HIV. NADCs now account for 50% of all cancers among the people. Smoking is one of the major contributing factors to lung cancer and smoking prevalence is substantially higher in this population than the general U.S. population. Smok...

Whole-body Vibration and Manual Ability

Purpose: To evaluate the short-term effects of whole-body vibration (WBV), using reciprocating plate technique, on manual ability performance in healthy younger. Material and methods: 38 healthy young volunteers were randomized to WBV group (N=19; 6 men, 13 women; mean age 21, 3.8yrs) or control group (N=19; 6 men, 13 women; mean age 20.5, 3.5yrs). The subjects in the WBV group performed one series of five consecutive repetitions of 60 sec unsynchronised WBV (Zeptoring, Scisen...


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