Riboflavin

Riboflavin, also known as vitamin B2, is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Vitamin B2 is a water-soluble vitamin, one that cannot be stored...

Vitamin E

Naturally occurring vitamin E exists in eight chemical forms (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) that have varying levels of biological act...

Individual hydroxymethylcytosine molecules in DNA detected by new method involving chemical modification and nanopore analysis

Changes in the bases that make up DNA act as markers, telling a cell which genes it should read and which it shouldn’t. In the journal Angewandte Chemie, a British team has now introduced a new meth...

An iron complex with pendent amines as a molecular electrocatalyst for oxidation of hydrogen

Electricity can be produced by the oxidation of hydrogen in fuel cells, but the best catalyst for this is platinum, a precious metal of low abundance. Now a molecular complex of iron, a very abundant,...

Pharmaceutical Research: Fluorogenic Tagging Methodology Applied to Characterize Oxidized Tyrosine and Phenylalanine in an Immunoglobulin Monoclonal Antibody

Type: Original PaperPurposeMetal-catalyzed oxidation (MCO) of proteins is of primary concern in the development of biotherapeutics as it represents a prominent degradation pathway with potential undes...

Biochemistry: Oxidation controls the DUB step

Reversible oxidation of amino-acid residues can directly regulate the activity of cellular enzymes. This principle has now been extended to deubiquitinating enzymes, with implications for cell signall...

Luoxis launches to market oxidation reduction Dx tool

Luoxis Diagnostics, an Ampio Pharmaceuticals unit, has launched operations to market the Oxidation Reduction Potential diagno -More- 

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming

Electrode-assisted catalytic water oxidation by a flavin derivative

So far, reports of molecular electrochemical water oxidation have involved catalytic transition metal complexes. Now it is demonstrated that water can be oxidized, and oxygen evolved, using a simple o...

Low testosterone levels affect total lipid oxidation

(HealthDay)—Very low testosterone levels impact total lipid oxidation but have no effect on the production of very-low-density lipoprotein-triglycerides (VLDL-TGs), according to a study published on...

5-Hydroxymethylcytosine-selective oxidation with peroxotungstate.

Tungsten oxidation worked as a simple chemical reaction for the effective detection of 5-hydroxymethylcytosine in DNA, distinguishing it from its epigenetic precursors, 5-methylcytosine and unmethylat...

Uncovering the role of 5-hydroxymethylcytosine in the epigenome.

Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epige...

A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences.

Treatment of DNA containing 5-formylcytosine with hot piperidine produced a cleaved band at the position of 5-formylcytosine in DNA sequences. After oxidation with KRuO4, 5-hydroxymethylcytosine could...

The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine.

5-Hydroxymethylcytosine (5hmC) is a newly discovered DNA base present at detectable levels in most mammalian cell types and tissues. It is generated by Tet-enzyme-mediated oxidation of 5-methylcytosin...

The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine.

5-hydroxymethylcytosine (5hmC) is a recently discovered base in the mammalian genome, produced upon oxidation of 5-methylcytosine (5mC) in a process catalyzed by TET proteins. The biological functions...