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Reprogramming Fibroblasts into Oligodendrocyte Progenitor Cells May Lead to Cure for Multiple ...

Working with mouse tissues, investigators have developed a method for converting skin or lung fibroblasts into fully functional...

MicroRNA Blockage of a Single Protein Induces Fibroblasts to Differentiate into Neurons

Inhibition of the activity of PTB by a specific microRNA is sufficient to induce fibroblasts to differentiate into functional...

Conversion of human fibroblasts to angioblast-like progenitor cells

Human fibroblasts undergo conversion to angioblast-like progenitors and then to endothelial cells by brief exposure to pluripotency factors, which is then followed by differentiation.

Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells

Expression of 8 or 3 defined transcription factors reprograms mouse embryonic fibroblasts to oligodendrocyte progenitor cells capable of generating myelinating oligodendrocytes.

Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion

Cancer-associated fibroblasts (CAFs) promote invasiveness in epithelial tumour cells via a cell non-autonomous mechanism involving reduced levels of retinoblastoma activity. This effect is caused in p...

Regulating single protein prompts fibroblasts to become neurons

Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells – abundantly found in connective tissues – into functional neurons. The findings, which could hav...

[Articles] Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial

Venous leg ulcers can be healed with a spray formulation of allogeneic neonatal keratinocytes and fibroblasts without the need for tissue engineering, at an optimum dose of 0·5×106 cells per mL ever...

Induced Pluripotent Stem Cells Generated Using Lentivirus-based Reprogramming

Five human induced pluripotent stem cells (iPSC) lines are generated using lentivirus-based reprogramming technology. These lines are pluripotent, meaning they have the potential to differentiate int...

The origin of fibroblasts and mechanism of cardiac fibrosis.

Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is e...

Multifaceted Tumor Stromal Fibroblasts.

Tumors are highly complex tissues composed of neoplastic cells and different kinds of stromal cells. Tumor stromal cells, especially fibroblasts, play important roles during the multistep development...

Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip.

We use a microfluidic cell culture chip equipped with pneumatic microvalves to analyze the paracrine loop between lung cancer cells and fibroblasts. In order to assess the cellular responses in the pa...

IL-8, IL-12 and IL-10 cytokines generation by neutrophils, fibroblasts and neutrophils- fibroblasts interaction in psoriasis.

Purpose: Psoriasis is a common skin disease affecting about 1-3% of the world population. Many types of cells, including lymphocytes, dendritics APCs (antigen presenting cells), NKT (natural killer T)...

Cytokine and matrix metalloproteinase expression in fibroblasts from peri-implantitis lesions in response to viable Porphyromonas gingivalis.

BACKGROUND AND OBJECTIVE: To assess inflammatory reactions of fibroblasts in the pathophysiology of peri-implantitis, we compared the pro-inflammatory and matrix-degrading responses of gingival and gr...