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Search Results for "Abnormal Immune Responses In Hiv Treated Patients"

06:23 EDT 19th June 2013 | BioPortfolio

Original Source: Immune Responses in Patients Treated With Raltegravir

Hypothesis: Treatment with raltegravir does not alter V(D)J recombination or immune responses to neoantigens. A process known as V(D)J recombination is essential for developing lymphocytes and the specific functioning of the immune system. Raltegravir is the first approved drug of the new integrase inhibitor class of anti-HIV drugs. Integrase inhibitors have been shown in some studies to interfere with DNA cleavage and the activities of RAG-1/2. These studies suggest a p...

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Immunovaccine?s DPX-Survivac Produces Sustained, Dose Related Immune Responses in Phase I Ovarian Cancer Study

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Immune responses can be generated locally within human melanoma skin metastases

(American Association for Cancer Research) Immune cell activation seen in skin metastases from melanoma patients. Structures supported active B lymphocyte responses.

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The anatomical and cellular basis of immune surveillance in the central nervous system

In this Review, the authors describe how immune responses are initiated and propagated against antigens found in the central nervous system (CNS). They explain how the unique anatomy of the CNS affect...

Stem cell technology could help harness patients' own immune cells to fight disease

Researchers reporting in two separate recent articles used stem cell technology to successfully regenerate patients' immune cells, creating large numbers that were long-lived and could recognize their...

New technique selectively dampens harmful immune responses

Current immune suppressants have major drawbacks, but medical researchers have now demonstrated a new technique that may lead to a better way to selectively repress unwanted immune reactions without d...

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Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial.

Dendritic cells (DC) are the most potent antigen presenting cells and have proven effective in stimulation of specific immune responses in vivo. Competing immune inhibition could limit the clinical ef...

Immune Activation Resulting From NKG2D/Ligand Interaction Promotes Atherosclerosis.

The interplay between the immune system and abnormal metabolic conditions sustains and propagates a vicious feedback cycle of chronic inflammation and metabolic dysfunction that is critical for athero...

A role for the heat shock protein-CD91 axis in the initiation of immune responses to tumors.

For over 100 years, it has been established that tumor-specific immune responses can frequently be detected in the tumor-bearing host. Whether or not these immune responses are capable of controlling...

The cellular immune response to influenza vaccination is preserved in rheumatoid arthritis patients treated with rituximab.

Yearly vaccination against influenza is currently recommended to patients with rheumatoid Arthritis (RA). Antibody and cell-mediated responses are both involved in the defense against influenza. Humor...

Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98.

The transmembrane glycoprotein CD98 is a potential regulator of multiple functions, including integrin signaling and amino acid transport. Abnormal expression or function of CD98 and disruption of the...

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